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Prediction of Survival by Tumor Area on Endosonography after Definitive Chemoradiotherapy for Locally Advanced Squamous Cell Carcinoma of the Esophagus

Authors
 Shim C.N.  ;  Song M.K.  ;  Lee H.S.  ;  Chung H.  ;  Lee H.  ;  Shin S.K.  ;  Lee S.K.  ;  Lee Y.C.  ;  Park J.C. 
Citation
 DIGESTION, Vol.90(2) : 98-107, 2014 
Journal Title
 DIGESTION 
ISSN
 0012-2823 
Issue Date
2014
MeSH
Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/diagnostic imaging* ; Carcinoma, Squamous Cell/mortality* ; Carcinoma, Squamous Cell/therapy ; Chemoradiotherapy ; Endosonography* ; Esophageal Neoplasms/diagnostic imaging* ; Esophageal Neoplasms/mortality* ; Esophageal Neoplasms/therapy ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Retrospective Studies
Keywords
Esophageal cancer ; Endosonography ; Tumor area ; Definitive chemoradiotherapy ; Progression-free survival
Abstract
Background: Definitive chemoradiotherapy (CRT) is a reasonable approach for patients with locally advanced esophageal cancer who are not surgical candidates. This study was performed to investigate whether endosonography (EUS) assessment of tumor area response is a useful prognostic marker in patients with squamous cell carcinoma (SCC) of the esophagus who receive definitive CRT. Methods: A total of 33 patients who received definitive CRT for locally advanced esophageal SCC were enrolled. The maximal transverse cross-sectional area of the tumor was measured before and after definitive therapy. EUS response was defined as a ≥50% reduction of the tumor area after definitive CRT. Results: Based on EUS evaluation, there were 20 nonresponders (60.6%) and 13 responders (39.4%). The median progression-free survival (PFS) was significantly longer in EUS responders than EUS nonresponders (p = 0.005). However, there was no statistical significance in overall survival according to EUS response (p = 0.120). During multivariate analysis, EUS response to definitive CRT was the only significant factor associated with PFS (p = 0.045), whereas EUS response to definitive CRT was not associated with overall survival (p = 0.221). Conclusions: A reduction of the maximal cross-sectional tumor area measured by EUS correlates with a superior prognosis in patients with locally advanced SCC of the esophagus after definitive CRT.
Full Text
http://www.karger.com/Article/FullText/365073
DOI
10.1159/000365073
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jun Chul(박준철) ORCID logo https://orcid.org/0000-0001-8018-0010
Song, Mi Kyung(송미경)
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Shim, Choong Nam(심충남)
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Lee, Hyuk(이혁)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99959
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