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Prediction of Survival by Tumor Area on Endosonography after Definitive Chemoradiotherapy for Locally Advanced Squamous Cell Carcinoma of the Esophagus

DC FieldValueLanguage
dc.contributor.author박준철-
dc.contributor.author송미경-
dc.contributor.author신성관-
dc.contributor.author심충남-
dc.contributor.author이상길-
dc.contributor.author이용찬-
dc.contributor.author이혁-
dc.contributor.author이혜선-
dc.contributor.author정현수-
dc.date.accessioned2015-01-06T17:25:40Z-
dc.date.available2015-01-06T17:25:40Z-
dc.date.issued2014-
dc.identifier.issn0012-2823-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99959-
dc.description.abstractBackground: Definitive chemoradiotherapy (CRT) is a reasonable approach for patients with locally advanced esophageal cancer who are not surgical candidates. This study was performed to investigate whether endosonography (EUS) assessment of tumor area response is a useful prognostic marker in patients with squamous cell carcinoma (SCC) of the esophagus who receive definitive CRT. Methods: A total of 33 patients who received definitive CRT for locally advanced esophageal SCC were enrolled. The maximal transverse cross-sectional area of the tumor was measured before and after definitive therapy. EUS response was defined as a ≥50% reduction of the tumor area after definitive CRT. Results: Based on EUS evaluation, there were 20 nonresponders (60.6%) and 13 responders (39.4%). The median progression-free survival (PFS) was significantly longer in EUS responders than EUS nonresponders (p = 0.005). However, there was no statistical significance in overall survival according to EUS response (p = 0.120). During multivariate analysis, EUS response to definitive CRT was the only significant factor associated with PFS (p = 0.045), whereas EUS response to definitive CRT was not associated with overall survival (p = 0.221). Conclusions: A reduction of the maximal cross-sectional tumor area measured by EUS correlates with a superior prognosis in patients with locally advanced SCC of the esophagus after definitive CRT.-
dc.description.statementOfResponsibilityopen-
dc.format.extent98~107-
dc.relation.isPartOfDIGESTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarcinoma, Squamous Cell/diagnostic imaging*-
dc.subject.MESHCarcinoma, Squamous Cell/mortality*-
dc.subject.MESHCarcinoma, Squamous Cell/therapy-
dc.subject.MESHChemoradiotherapy-
dc.subject.MESHEndosonography*-
dc.subject.MESHEsophageal Neoplasms/diagnostic imaging*-
dc.subject.MESHEsophageal Neoplasms/mortality*-
dc.subject.MESHEsophageal Neoplasms/therapy-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.titlePrediction of Survival by Tumor Area on Endosonography after Definitive Chemoradiotherapy for Locally Advanced Squamous Cell Carcinoma of the Esophagus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorShim C.N.-
dc.contributor.googleauthorSong M.K.-
dc.contributor.googleauthorLee H.S.-
dc.contributor.googleauthorChung H.-
dc.contributor.googleauthorLee H.-
dc.contributor.googleauthorShin S.K.-
dc.contributor.googleauthorLee S.K.-
dc.contributor.googleauthorLee Y.C.-
dc.contributor.googleauthorPark J.C.-
dc.identifier.doi10.1159/000365073-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01676-
dc.contributor.localIdA02020-
dc.contributor.localIdA02112-
dc.contributor.localIdA02214-
dc.contributor.localIdA02812-
dc.contributor.localIdA02988-
dc.contributor.localIdA03285-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ00734-
dc.identifier.eissn1421-9867-
dc.identifier.pmid25196528-
dc.identifier.urlhttp://www.karger.com/Article/FullText/365073-
dc.subject.keywordEsophageal cancer-
dc.subject.keywordEndosonography-
dc.subject.keywordTumor area-
dc.subject.keywordDefinitive chemoradiotherapy-
dc.subject.keywordProgression-free survival-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNameSong, Mi Kyung-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameShim, Choong Nam-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameLee, Hyuk-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameChung, Hyun Soo-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorSong, Mi Kyung-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorShim, Choong Nam-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorLee, Hyuk-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.rights.accessRightsfree-
dc.citation.volume90-
dc.citation.number2-
dc.citation.startPage98-
dc.citation.endPage107-
dc.identifier.bibliographicCitationDIGESTION, Vol.90(2) : 98-107, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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