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Relationship between visual acuity and retinal structures measured by spectral domain optical coherence tomography in patients with open-angle glaucoma

Authors
 Ji Hyun Kim  ;  Hye Sun Lee  ;  Na Rae Kim  ;  Gong Je Seong  ;  Chan Yun Kim 
Citation
 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol.55(8) : 4801-4810, 2014 
Journal Title
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
ISSN
 0146-0404 
Issue Date
2014
MeSH
Cross-Sectional Studies ; Female ; Follow-Up Studies ; Glaucoma, Open-Angle/diagnosis* ; Glaucoma, Open-Angle/physiopathology ; Humans ; Male ; Middle Aged ; Nerve Fibers/pathology ; ROC Curve ; Retinal Ganglion Cells/pathology* ; Retrospective Studies ; Severity of Illness Index ; Tomography, Optical Coherence/methods* ; Visual Acuity* ; Visual Fields
Keywords
ganglion cell complex ; optical coherence tomography ; retinal nerve fiber layer thickness ; visual acuity
Abstract
PURPOSE:
We assessed the relationship between retinal structures measured by spectral-domain optical coherence tomography (SD-OCT) and visual acuity in open-angle glaucoma (OAG) patients.
METHODS:
In this cross-sectional observational study, 186 eyes from 186 OAG patients were included. The participants underwent RTVue OCT for measurement of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular ganglion cell complex (mGCC) thickness. The correlations between best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) parameters were evaluated using Pearson's partial correlation test and regression analysis. Receiver operating characteristic (ROC) curve analysis was performed to obtain a cutoff value for OCT parameters in detecting decreased visual acuity (BCVA < 0.7).
RESULTS:
Among RNFL parameters, average RNFL thickness (r = -0.447, P < 0.001) showed the highest correlation with BCVA, followed by superior hemisphere (r = -0.440, P <0.001), and TU1 (67.5°-90°, r = -0.427, P < 0.001), TU2 (45°-67.5°, r = -0.408, P < 0.001), and TL1 (90°-112.5°, r = -0.40, P < 0.001) sectors. When logMAR BCVA was plotted against average RNFL/ganglion cell complex (GCC) thickness, second-order polynomial models fit better than the linear model. The areas under the receiver operating characteristic curves (AUROCs) of the average RNFL/GCC thickness were 0.910 (95% confidence interval [CI], 0.856-0.965) and 0.874 (95% CI, 0.795-0.953), respectively.
CONCLUSIONS:
The relationship between BCVA and SD-OCT parameters were curvilinear, and significant correlations were noted only in eyes with severe glaucoma. The global average cpRNFL thickness showed the highest correlation with BCVA rather than TU1, TL1 sectors, or GCC parameters. Considering the wide variability of structure-visual acuity relationship in glaucoma patients, the clinicians should take other variables into account to predict the visual acuity in advanced glaucoma patients.
Full Text
http://www.iovs.org/content/55/8/4801.long
DOI
10.1167/iovs.13-13052
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99640
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