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The Role of High Mobility Group Box 1 in Innate Immunity

Authors
 Shin-Ae Lee  ;  Man Sup Kwak  ;  Sol Kim  ;  Jeon-Soo Shin 
Citation
 YONSEI MEDICAL JOURNAL, Vol.55(5) : 1165-1176, 2014 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2014
MeSH
Amino Acid Sequence ; HMGB1 Protein/chemistry ; HMGB1 Protein/metabolism ; HMGB1 Protein/physiology* ; Humans ; Immunity, Innate/physiology* ; Models, Immunological* ; Molecular Sequence Data ; Protein Structure, Tertiary ; Signal Transduction
Keywords
DAMP ; HMGB1 ; inflammation ; innate immunity
Abstract
With growing accounts of inflammatory diseases such as sepsis, greater understanding the immune system and the mechanisms of cellular immunity have become primary objectives in immunology studies. High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is implicated in various aspects of the innate immune system as a damage-associated molecular pattern molecule and a late mediator of inflammation, as well as in principal cellular processes, such as autophagy and apoptosis. HMGB1 functions in the nucleus as a DNA chaperone; however, it exhibits cytokine-like activity when secreted by injurious or infectious stimuli. Extracellular HMGB1 acts through specific receptors to promote activation of the NF-κB signaling pathway, leading to production of cytokines and chemokines. These findings further implicate HMGB1 in lethal inflammatory diseases as a crucial regulator of inflammatory, injurious, and infectious responses. In this paper, we summarize the role of HMGB1 in inflammatory and non-inflammatory states and assess potential therapeutic approaches targeting HMGB1 in inflammatory diseases.
Files in This Item:
T201402283.pdf Download
DOI
10.3349/ymj.2014.55.5.1165
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Man Sup(곽만섭) ORCID logo https://orcid.org/0000-0002-3989-3016
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99244
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