5 423

Cited 13 times in

Association between genetic variants in the IRGM gene and tuberculosis in a Korean population

Authors
 J. H. Song  ;  S. Y. Kim  ;  K. S. Chung  ;  C. M. Moon  ;  S. W. Kim  ;  E. Y. Kim  ;  J. Y. Jung  ;  M. S. Park  ;  Y. S. Kim  ;  S. K. Kim  ;  J. Chang  ;  D. J. Shin  ;  Y. A. Kang 
Citation
 INFECTION, Vol.42(4) : 655-660, 2014 
Journal Title
 INFECTION 
ISSN
 0300-8126 
Issue Date
2014
MeSH
Adult ; Aged ; Case-Control Studies ; Female ; GTP-Binding Proteins/genetics* ; Gene Frequency ; Genetic Predisposition to Disease* ; Genotype ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Prospective Studies ; Republic of Korea/epidemiology ; Tuberculosis/epidemiology* ; Tuberculosis/genetics* ; Tuberculosis/immunology ; Young Adult
Keywords
IRGM ; Autophagy ; Tuberculosis ; Single-nucleotide polymorphism
Abstract
PURPOSE: To investigate immunity-related guanosine triphosphatase family M (IRGM) genetic variants associated with susceptibility to tuberculosis (TB) in a Korean population. METHODS: We conducted a prospective case-control study including 193 patients with active TB in Severance Hospital and 230 age- and sex-matched unrelated controls registered in Yonsei Cardiovascular Genome Center. Based on associations with other chronic inflammatory conditions, we analyzed the allele and genotype frequencies of rs72553867, rs10065172, and rs12654043 among patients with TB and healthy controls. RESULTS:The T allele of rs10065172 was significantly associated with protection against developing TB based on allele frequency [P = 0.042; odds ratio (OR) 0.75] and genotype distribution in the codominant model (P = 0.036; OR 0.73). CONCLUSIONS:This is the first study to identify a significant association between the IRGM single-nucleotide polymorphism (SNP) rs10065172 and susceptibility to active TB disease in an Asian population. The results suggest that IRGM genetic variants could be associated with susceptibility to active TB disease in the Korean population.
Full Text
http://link.springer.com/article/10.1007%2Fs15010-014-0604-6
DOI
10.1007/s15010-014-0604-6
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Se Kyu(김세규)
Kim, Song Yee(김송이) ORCID logo https://orcid.org/0000-0001-8627-486X
Kim, Seung Won(김승원) ORCID logo https://orcid.org/0000-0002-1692-1192
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Eun Young(김은영) ORCID logo https://orcid.org/0000-0002-3281-5744
Moon, Chang Mo(문창모)
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Song, Joo Han(송주한)
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Jung, Kyung Soo(정경수) ORCID logo https://orcid.org/0000-0003-1604-8730
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99192
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse