Cited 17 times in
Association between genetic variants in the IRGM gene and tuberculosis in a Korean population
DC Field | Value | Language |
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dc.contributor.author | 강영애 | - |
dc.contributor.author | 김세규 | - |
dc.contributor.author | 김송이 | - |
dc.contributor.author | 김승원 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 김은영 | - |
dc.contributor.author | 문창모 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 송주한 | - |
dc.contributor.author | 신동직 | - |
dc.contributor.author | 장준 | - |
dc.contributor.author | 정경수 | - |
dc.contributor.author | 정지예 | - |
dc.date.accessioned | 2015-01-06T17:00:27Z | - |
dc.date.available | 2015-01-06T17:00:27Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0300-8126 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99192 | - |
dc.description.abstract | PURPOSE: To investigate immunity-related guanosine triphosphatase family M (IRGM) genetic variants associated with susceptibility to tuberculosis (TB) in a Korean population. METHODS: We conducted a prospective case-control study including 193 patients with active TB in Severance Hospital and 230 age- and sex-matched unrelated controls registered in Yonsei Cardiovascular Genome Center. Based on associations with other chronic inflammatory conditions, we analyzed the allele and genotype frequencies of rs72553867, rs10065172, and rs12654043 among patients with TB and healthy controls. RESULTS:The T allele of rs10065172 was significantly associated with protection against developing TB based on allele frequency [P = 0.042; odds ratio (OR) 0.75] and genotype distribution in the codominant model (P = 0.036; OR 0.73). CONCLUSIONS:This is the first study to identify a significant association between the IRGM single-nucleotide polymorphism (SNP) rs10065172 and susceptibility to active TB disease in an Asian population. The results suggest that IRGM genetic variants could be associated with susceptibility to active TB disease in the Korean population. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 655~660 | - |
dc.relation.isPartOf | INFECTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | GTP-Binding Proteins/genetics* | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease* | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Tuberculosis/epidemiology* | - |
dc.subject.MESH | Tuberculosis/genetics* | - |
dc.subject.MESH | Tuberculosis/immunology | - |
dc.subject.MESH | Young Adult | - |
dc.title | Association between genetic variants in the IRGM gene and tuberculosis in a Korean population | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | J. H. Song | - |
dc.contributor.googleauthor | S. Y. Kim | - |
dc.contributor.googleauthor | K. S. Chung | - |
dc.contributor.googleauthor | C. M. Moon | - |
dc.contributor.googleauthor | S. W. Kim | - |
dc.contributor.googleauthor | E. Y. Kim | - |
dc.contributor.googleauthor | J. Y. Jung | - |
dc.contributor.googleauthor | M. S. Park | - |
dc.contributor.googleauthor | Y. S. Kim | - |
dc.contributor.googleauthor | S. K. Kim | - |
dc.contributor.googleauthor | J. Chang | - |
dc.contributor.googleauthor | D. J. Shin | - |
dc.contributor.googleauthor | Y. A. Kang | - |
dc.identifier.doi | 10.1007/s15010-014-0604-6 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A00602 | - |
dc.contributor.localId | A00626 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A01390 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A02062 | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03570 | - |
dc.contributor.localId | A03735 | - |
dc.contributor.localId | A00811 | - |
dc.contributor.localId | A00656 | - |
dc.relation.journalcode | J01052 | - |
dc.identifier.eissn | 1439-0973 | - |
dc.identifier.pmid | 24595493 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs15010-014-0604-6 | - |
dc.subject.keyword | IRGM | - |
dc.subject.keyword | Autophagy | - |
dc.subject.keyword | Tuberculosis | - |
dc.subject.keyword | Single-nucleotide polymorphism | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.alternativeName | Kim, Se Kyu | - |
dc.contributor.alternativeName | Kim, Song Yi | - |
dc.contributor.alternativeName | Kim, Seung Won | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Kim, Eun Young | - |
dc.contributor.alternativeName | Moon, Chang Mo | - |
dc.contributor.alternativeName | Park, Moo Suk | - |
dc.contributor.alternativeName | Song, Joo Han | - |
dc.contributor.alternativeName | Shin, Dong Jik | - |
dc.contributor.alternativeName | Chang, Joon | - |
dc.contributor.alternativeName | Jung, Kyung Soo | - |
dc.contributor.alternativeName | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | Kim, Se Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Song Yi | - |
dc.contributor.affiliatedAuthor | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | Moon, Chang Mo | - |
dc.contributor.affiliatedAuthor | Park, Moo Suk | - |
dc.contributor.affiliatedAuthor | Song, Joo Han | - |
dc.contributor.affiliatedAuthor | Chang, Joon | - |
dc.contributor.affiliatedAuthor | Jung, Kyung Soo | - |
dc.contributor.affiliatedAuthor | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Kim, Eun Young | - |
dc.contributor.affiliatedAuthor | Kim, Seung Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 42 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 655 | - |
dc.citation.endPage | 660 | - |
dc.identifier.bibliographicCitation | INFECTION, Vol.42(4) : 655-660, 2014 | - |
dc.identifier.rimsid | 51205 | - |
dc.type.rims | ART | - |
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