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Ridge preservation using demineralized bone matrix gel with recombinant human bone morphogenetic protein-2 after tooth extraction: A randomized controlled clinical trial

Authors
 Yu-Jin Kim  ;  Jeong-Yol Lee  ;  Jong-Eun Kim  ;  Jung-Chul Park  ;  Sang-Wan Shin  ;  Kyoo-Sung Cho 
Citation
 JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, Vol.72(7) : 1281-1290, 2014 
Journal Title
 JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 
ISSN
 0278-2391 
Issue Date
2014
MeSH
Adult ; Alveolar Bone Loss/prevention & control* ; Alveolar Process/diagnostic imaging ; Alveolar Process/surgery* ; Bone Morphogenetic Protein 2/administration & dosage ; Bone Morphogenetic Protein 2/therapeutic use* ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/therapeutic use ; Single-Blind Method ; Tomography, X-Ray Computed ; Tooth Extraction/adverse effects* ; Transforming Growth Factor beta/administration & dosage ; Transforming Growth Factor beta/therapeutic use*
Abstract
PURPOSE: The aim of the present randomized controlled trial was to determine the safety and efficacy of injectable demineralized bone matrix (DBM) gel combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) on alveolar ridge preservation after tooth extraction. MATERIALS AND METHODS:A total of 69 patients were randomly assigned to either a test group (n = 35) or a control group (n = 34). In the test group, DBM, together with rhBMP-2 (0.05 mg/mL; rhBMP-2/DBM) was transplanted into the extraction sockets. The control group received DBM alone. The safety of rhBMP-2/DBM was evaluated by oral examination, serum chemistry, and hematologic examination. The radiographic changes in alveolar bone height and width were measured using computed tomography scans performed immediately after transplant and again 3 months thereafter. RESULTS:Healing was uneventful in all subjects, with no anticipated adverse events and no clinically significant changes in the serum chemistry and hematologic findings. No meaningful immune response was found among the study groups. No significant difference was found in the radiographic changes of alveolar bone height and width (P > .05). CONCLUSIONS:This new injectable biomaterial can be used easily and safely in clinical applications.
Full Text
http://www.sciencedirect.com/science/article/pii/S0278239114001487
DOI
10.1016/j.joms.2014.01.022
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Eun(김종은) ORCID logo https://orcid.org/0000-0002-7834-2524
Park, Jung Chul(박정철)
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99135
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