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Vascular Soft-Tissue Sarcomas: A Prognostic Model from a Retrospective Single-Center Study

Authors
 Park K.S.  ;  Kim H.S.  ;  Cho Y.J.  ;  Rha S.Y.  ;  Ahn J.B.  ;  Yang W.I.  ;  Lee Y.H.  ;  Suh J.-S.  ;  Shin K.-H.  ;  Roh J.K. 
Citation
 Oncology, Vol.86(5-6) : 329-335, 2014 
Journal Title
 Oncology 
ISSN
 0030-2414 
Issue Date
2014
Abstract
Background: Vascular soft-tissue sarcomas are a rare form of sarcoma. Malignant subtypes exhibit a variety of biological behaviors. We describe the clinicopathological characteristics and patient survival outcomes of malignant vascular soft-tissue sarcomas. Methods: We conducted a retrospective study on a cohort of 84 patients diagnosed with vascular tumors by histological examination at the Yonsei University College of Medicine between April 1987 and August 2011. The primary end point was overall survival (OS). Results: The angiosarcoma patients had a significantly shorter OS than the patients with other subtypes of sarcomas (59.0 and 142.7 months, respectively; p < 0.001). Upon multivariate analysis of survival in patients who underwent surgical resection, the following independent prognostic factors were identified: primary site (trunk, p = 0.001), age (older than 65 years, p < 0.001), pathology (angiosarcoma, p = 0.006) and R2 resection (p = 0.002). Conclusion: The independent prognostic factors for shorter survival are the trunk as the primary site, malignant angiosarcoma and age (>65 years). Complete excision should be attempted for providing a survival advantage in the patients with localized disease. In addition, bleeding episodes are much more frequent in patients with a poor survival outcome.
Full Text
http://www.karger.com/Article/FullText/358804
DOI
10.1159/000358804
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김효송(Kim, Hyo Song) ORCID logo https://orcid.org/0000-0002-0625-9828
노재경(Roh, Jae Kyung)
라선영(Rha, Sun Young) ORCID logo https://orcid.org/0000-0002-2512-4531
박경숙(Park, Kyoung Sook)
서진석(Suh, Jin Suck) ORCID logo https://orcid.org/0000-0001-9455-9240
신규호(Shin, Kyoo Ho)
안중배(Ahn, Joong Bae) ORCID logo https://orcid.org/0000-0001-6787-1503
양우익(Yang, Woo Ick) ORCID logo https://orcid.org/0000-0002-6084-5019
이영한(Lee, Young Han) ORCID logo https://orcid.org/0000-0002-5602-391X
조영진(Cho, Yong Jin)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99088
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