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Vascular Soft-Tissue Sarcomas: A Prognostic Model from a Retrospective Single-Center Study

Authors
 Park K.S.  ;  Kim H.S.  ;  Cho Y.J.  ;  Rha S.Y.  ;  Ahn J.B.  ;  Yang W.I.  ;  Lee Y.H.  ;  Suh J.-S.  ;  Shin K.-H.  ;  Roh J.K. 
Citation
 ONCOLOGY, Vol.86(5-6) : 329-335, 2014 
Journal Title
ONCOLOGY
ISSN
 0030-2414 
Issue Date
2014
MeSH
Aged ; Female ; Hemangiosarcoma/mortality ; Hemangiosarcoma/pathology* ; Hemangiosarcoma/surgery ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Treatment Outcome
Keywords
Vascular soft-tissue sarcoma ; Angiosarcoma ; Sarcoma
Abstract
Background: Vascular soft-tissue sarcomas are a rare form of sarcoma. Malignant subtypes exhibit a variety of biological behaviors. We describe the clinicopathological characteristics and patient survival outcomes of malignant vascular soft-tissue sarcomas. Methods: We conducted a retrospective study on a cohort of 84 patients diagnosed with vascular tumors by histological examination at the Yonsei University College of Medicine between April 1987 and August 2011. The primary end point was overall survival (OS). Results: The angiosarcoma patients had a significantly shorter OS than the patients with other subtypes of sarcomas (59.0 and 142.7 months, respectively; p < 0.001). Upon multivariate analysis of survival in patients who underwent surgical resection, the following independent prognostic factors were identified: primary site (trunk, p = 0.001), age (older than 65 years, p < 0.001), pathology (angiosarcoma, p = 0.006) and R2 resection (p = 0.002). Conclusion: The independent prognostic factors for shorter survival are the trunk as the primary site, malignant angiosarcoma and age (>65 years). Complete excision should be attempted for providing a survival advantage in the patients with localized disease. In addition, bleeding episodes are much more frequent in patients with a poor survival outcome.
Full Text
http://www.karger.com/Article/FullText/358804
DOI
10.1159/000358804
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyo Song(김효송) ORCID logo https://orcid.org/0000-0002-0625-9828
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Park, Kyoung Sook(박경숙)
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Shin, Kyoo Ho(신규호)
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Young Han(이영한) ORCID logo https://orcid.org/0000-0002-5602-391X
Cho, Yong Jin(조용진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99088
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