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Neoadjuvant intra-arterial chemotherapy in patients with primary lacrimal adenoid cystic carcinoma

Authors
 Sun Young Jang  ;  Dong Joon Kim  ;  Chang Yeom Kim  ;  Cheng Zhe Wu  ;  Jin Sook Yoon  ;  Sang Yeul Lee 
Citation
 CANCER IMAGING, Vol.14(19) : 1-8, 2014 
Journal Title
 CANCER IMAGING 
ISSN
 1470-7330 
Issue Date
2014
MeSH
Adult ; Aged ; Carcinoma, Adenoid Cystic/drug therapy* ; Carcinoma, Adenoid Cystic/mortality ; Eye Neoplasms/drug therapy* ; Eye Neoplasms/mortality ; Female ; Humans ; Injections, Intra-Arterial ; Lacrimal Apparatus/pathology* ; Male ; Middle Aged ; Neoadjuvant Therapy
Keywords
Adenoid cystic carcinoma ; Neoadjuvant intra-arterial chemotherapy ; Complication
Abstract
Background : We describe four cases of primary lacrimal adenoid cystic carcinoma (ACC) treated with neoadjuvant intra-arterial chemotherapy (NAIC). Methods : The outcomes and complications of NAIC were reviewed. Several treatment-related local and/or systemic complications were noted. Results : One patient experienced ipsilateral eyelid and eyeball necrosis and permanent facial palsy; the second patient developed ipsilateral facial swelling and jaw claudication; and the third patient had febrile neutropenia, cellulitis, and phlebitis. These three patients underwent total exenteration. The fourth patient experienced neutropenia and thrombocytopenia and underwent tumour removal without exenteration. All patients were followed for more than 4 years and were alive at the last follow-up. Conclusion : Neoadjuvant intra-arterial chemotherapy may be an alternative treatment that will improve the survival rate of ACC. However, careful and close observation is needed to minimise the risk of side effects. Further investigations are needed to justify the use of chemotherapy-related treatments and the associated costs.
Full Text
http://link.springer.com/article/10.1186%2F1470-7330-14-19
DOI
10.1186/1470-7330-14-19
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Joon(김동준) ORCID logo https://orcid.org/0000-0002-7035-087X
Kim, Chang Yeom(김창염)
Yoon, Jin Sook(윤진숙) ORCID logo https://orcid.org/0000-0002-8751-9467
Lee, Sang Yeul(이상열)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98893
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