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Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors

Authors
 Ung Yeol Lee  ;  Young Taik Oh  ;  Dongin Kim  ;  Eun Seong Lee 
Citation
 INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.471(1-2) : 166-172, 2014 
Journal Title
 INTERNATIONAL JOURNAL OF PHARMACEUTICS 
ISSN
 0378-5173 
Issue Date
2014
MeSH
Animals ; Cell Line, Tumor ; Drug Carriers/chemistry* ; Drug Liberation ; Female ; Humans ; Magnetic Resonance Imaging/methods* ; Magnetite Nanoparticles/chemistry* ; Mice, Nude ; Micelles ; Neoplasms*/drug therapy ; Neoplasms*/pathology ; Photochemotherapy/methods* ; Porphyrins/administration & dosage* ; Porphyrins/chemistry ; Radiation-Sensitizing Agents/administration & dosage* ; Radiation-Sensitizing Agents/chemistry ; Surface Properties ; Xenograft Model Antitumor Assays
Keywords
Chlorin e6 (Ce6) ; Grain-marked micelles ; Magnetic resonance imaging ; Multimeric micelles ; Photodynamic therapy
Abstract
Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.
Full Text
http://www.sciencedirect.com/science/article/pii/S0378517314003688
DOI
10.1016/j.ijpharm.2014.05.028
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98879
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