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Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors

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dc.contributor.author오영택-
dc.date.accessioned2015-01-06T16:50:42Z-
dc.date.available2015-01-06T16:50:42Z-
dc.date.issued2014-
dc.identifier.issn0378-5173-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98879-
dc.description.abstractMultimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.-
dc.description.statementOfResponsibilityopen-
dc.format.extent166~172-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHDrug Carriers/chemistry*-
dc.subject.MESHDrug Liberation-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging/methods*-
dc.subject.MESHMagnetite Nanoparticles/chemistry*-
dc.subject.MESHMice, Nude-
dc.subject.MESHMicelles-
dc.subject.MESHNeoplasms*/drug therapy-
dc.subject.MESHNeoplasms*/pathology-
dc.subject.MESHPhotochemotherapy/methods*-
dc.subject.MESHPorphyrins/administration & dosage*-
dc.subject.MESHPorphyrins/chemistry-
dc.subject.MESHRadiation-Sensitizing Agents/administration & dosage*-
dc.subject.MESHRadiation-Sensitizing Agents/chemistry-
dc.subject.MESHSurface Properties-
dc.subject.MESHXenograft Model Antitumor Assays-
dc.titleMultimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorUng Yeol Lee-
dc.contributor.googleauthorYoung Taik Oh-
dc.contributor.googleauthorDongin Kim-
dc.contributor.googleauthorEun Seong Lee-
dc.identifier.doi10.1016/j.ijpharm.2014.05.028-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02390-
dc.relation.journalcodeJ01150-
dc.identifier.eissn1873-3476-
dc.identifier.pmid24858385-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0378517314003688-
dc.subject.keywordChlorin e6 (Ce6)-
dc.subject.keywordGrain-marked micelles-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordMultimeric micelles-
dc.subject.keywordPhotodynamic therapy-
dc.contributor.alternativeNameOh, Young Taik-
dc.contributor.affiliatedAuthorOh, Young Taik-
dc.rights.accessRightsfree-
dc.citation.volume471-
dc.citation.number1-2-
dc.citation.startPage166-
dc.citation.endPage172-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.471(1-2) : 166-172, 2014-
dc.identifier.rimsid38841-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
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