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Surface charge switching nanoparticles for magnetic resonance imaging

Authors
 Dong Jin Lee  ;  Young Taik Oh  ;  Eun Seong Lee 
Citation
 INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.471(1-2) : 127-134, 2014 
Journal Title
 INTERNATIONAL JOURNAL OF PHARMACEUTICS 
ISSN
 0378-5173 
Issue Date
2014
MeSH
Animals ; Cell Line, Tumor ; Contrast Media/chemistry* ; Deoxycholic Acid/analogs & derivatives* ; Deoxycholic Acid/chemistry ; Female ; Flow Cytometry ; Humans ; Magnetic Resonance Imaging* ; Magnetite Nanoparticles/chemistry* ; Mice, Nude ; Microscopy, Confocal ; Microscopy, Fluorescence ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Particle Size ; Polylysine/chemistry* ; Static Electricity ; Surface Properties
Keywords
Fe(3)O(4) ; Magnetic resonance imaging (MRI) ; Surface charge switching nanoparticle ; pH-Responsive
Abstract
In this study, polypeptide-based nanoparticles [constituted using poly(l-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe3O4-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.
Full Text
http://www.sciencedirect.com/science/article/pii/S037851731400369X
DOI
10.1016/j.ijpharm.2014.05.029
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98845
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