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Optimal indication of thyroglobulin measurement in fine-needle aspiration for detecting lateral metastatic lymph nodes in patients with papillary thyroid carcinoma

Authors
 Jin Chung  ;  Eun Kyung Kim  ;  Hyunsun Lim  ;  Eun Ju Son  ;  Jung Hyun Yoon  ;  Ji Hyun Youk  ;  Jeong-Ah Kim  ;  Hee Jung Moon  ;  Jin Young Kwak 
Citation
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.36(6) : 795-801, 2014 
Journal Title
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 
ISSN
 1043-3074 
Issue Date
2014
MeSH
Adult ; Biomarkers/blood* ; Biopsy, Fine-Needle* ; Carcinoma/blood ; Carcinoma/pathology* ; Carcinoma/secondary* ; Carcinoma, Papillary ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Predictive Value of Tests ; Retrospective Studies ; Sensitivity and Specificity ; Thyroglobulin/blood* ; Thyroid Neoplasms/blood ; Thyroid Neoplasms/pathology* ; Thyroid Neoplasms/secondary*
Keywords
fine-needle aspiration ; lymph node metastasis ; papillary thyroid carcinoma ; thyroglobulin ; ultrasound
Abstract
BACKGROUND: The purpose of this study was to evaluate optimal indication of thyroglobulin (Tg) measurement in fine-needle aspiration (FNA) for detecting lateral metastatic lymph nodes in patients with papillary thyroid carcinoma (PTC). METHODS: We performed a retrospective study of 241 lymph nodes of 220 patients who underwent ultrasound-guided FNA with Tg in FNA (FNA-Tg) washout fluid measurements for suspicious lymph nodes. RESULTS: On multivariate analysis, hyperechogenicity, cystic change, presence of calcifications, and peripheral vascularity were independent factors predictive of lymph node metastasis. After adding FNA-Tg, sensitivity and accuracy were significantly increased when the lymph node had 1 or 2 suspicious ultrasound features. However, sensitivity and accuracy were not significantly increased when the lymph node had multiple suspicious ultrasound features. CONCLUSION: Additional FNA-Tg can help diagnose a metastatic lymph node with 1 or 2 suspicious ultrasound features. However, additional FNA-Tg is not beneficial in lymph nodes with highly suspicious ultrasound features, in which FNA alone is sufficient for diagnosis of predictive of lymph node.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.23371/abstract
DOI
10.1002/hed.23371
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Kim, Jeong Ah(김정아) ORCID logo https://orcid.org/0000-0003-4949-4913
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
Lim, Hyun Sun(임현선)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98745
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