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Tumor perfusion-related parameter of diffusion-weighted magnetic resonance imaging: Correlation with histological microvessel density

Authors
 Hye-Jeong Lee  ;  Sun Young Rha  ;  Yong Eun Chung  ;  Hyo Sub Shim  ;  Young Jin Kim  ;  Jin Hur  ;  Yoo Jin Hong  ;  Byoung Wook Choi 
Citation
 MAGNETIC RESONANCE IN MEDICINE, Vol.71(4) : 1554-1558, 2014 
Journal Title
 MAGNETIC RESONANCE IN MEDICINE 
ISSN
 0740-3194 
Issue Date
2014
MeSH
Animals ; Diffusion Magnetic Resonance Imaging/methods* ; HT29 Cells ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods* ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Microvessels/pathology* ; Neoplasms, Experimental/complications* ; Neoplasms, Experimental/pathology* ; Neovascularization, Pathologic/complications* ; Neovascularization, Pathologic/pathology* ; Reproducibility of Results ; Sensitivity and Specificity ; Statistics as Topic
Keywords
angiogenesis ; diffusion-weighted MRI ; intravoxel incoherent motion ; microvessel density ; tumor
Abstract
PURPOSE: We obtained intravoxel incoherent motion (IVIM) parameters through biexponential analysis on diffusion-weighted MR imaging (DWI) using multiple b values. Correlation was evaluated between these parameters and histological microvessel density (MVD) for the possibility of noninvasive evaluation of MVD with DWI. METHODS: Twenty-five nude mice with the HT29 colorectal cancer cells implanted were analyzed after undergoing DWI with multiple b values (0, 50, 100, 300, 500, 700, and 1000 s/mm(2)). Tissue diffusivity (D(t)), pseudo-diffusion coefficient (D(p)), and perfusion fraction (f(p)) were calculated using a biexponential analysis, and these parameters were correlated with MVD. The MVD was determined with the CD31 stain. For statistical analysis, Spearman's rank correlation was applied. RESULTS: The mean value and correlation coefficient with MVD for each IVIM parameter were as follows: D(t)  = 0.98 ± 0.06 × 10(-3) mm(2)/s with r = 0.139 (P = 0.508); D(p) = 23.70 ± 7.94 × 10(-3) mm(2)/s with r = 0.782 (P < 0.001); and f(p) = 15.58 ± 5.7% with r = 0.749 (P < 0.001). D(p) and f(p) showed significant correlation with MVD, but D(t) did not. CONCLUSION: The IVIM parameters, D(p) and f(p), on DWI might be used in the noninvasive evaluation of MVD.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mrm.24810/abstract
DOI
10.1002/mrm.24810
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
Hong, Yoo Jin(홍유진) ORCID logo https://orcid.org/0000-0002-7276-0944
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98603
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