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Tumor perfusion-related parameter of diffusion-weighted magnetic resonance imaging: Correlation with histological microvessel density

DC FieldValueLanguage
dc.contributor.author정용은-
dc.contributor.author최병욱-
dc.contributor.author허진-
dc.contributor.author홍유진-
dc.contributor.author김영진-
dc.contributor.author라선영-
dc.contributor.author심효섭-
dc.contributor.author이혜정-
dc.date.accessioned2015-01-06T16:42:14Z-
dc.date.available2015-01-06T16:42:14Z-
dc.date.issued2014-
dc.identifier.issn0740-3194-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98603-
dc.description.abstractPURPOSE: We obtained intravoxel incoherent motion (IVIM) parameters through biexponential analysis on diffusion-weighted MR imaging (DWI) using multiple b values. Correlation was evaluated between these parameters and histological microvessel density (MVD) for the possibility of noninvasive evaluation of MVD with DWI. METHODS: Twenty-five nude mice with the HT29 colorectal cancer cells implanted were analyzed after undergoing DWI with multiple b values (0, 50, 100, 300, 500, 700, and 1000 s/mm(2)). Tissue diffusivity (D(t)), pseudo-diffusion coefficient (D(p)), and perfusion fraction (f(p)) were calculated using a biexponential analysis, and these parameters were correlated with MVD. The MVD was determined with the CD31 stain. For statistical analysis, Spearman's rank correlation was applied. RESULTS: The mean value and correlation coefficient with MVD for each IVIM parameter were as follows: D(t)  = 0.98 ± 0.06 × 10(-3) mm(2)/s with r = 0.139 (P = 0.508); D(p) = 23.70 ± 7.94 × 10(-3) mm(2)/s with r = 0.782 (P < 0.001); and f(p) = 15.58 ± 5.7% with r = 0.749 (P < 0.001). D(p) and f(p) showed significant correlation with MVD, but D(t) did not. CONCLUSION: The IVIM parameters, D(p) and f(p), on DWI might be used in the noninvasive evaluation of MVD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1554~1558-
dc.relation.isPartOfMAGNETIC RESONANCE IN MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHDiffusion Magnetic Resonance Imaging/methods*-
dc.subject.MESHHT29 Cells-
dc.subject.MESHHumans-
dc.subject.MESHImage Enhancement/methods-
dc.subject.MESHImage Interpretation, Computer-Assisted/methods*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Nude-
dc.subject.MESHMicrovessels/pathology*-
dc.subject.MESHNeoplasms, Experimental/complications*-
dc.subject.MESHNeoplasms, Experimental/pathology*-
dc.subject.MESHNeovascularization, Pathologic/complications*-
dc.subject.MESHNeovascularization, Pathologic/pathology*-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHStatistics as Topic-
dc.titleTumor perfusion-related parameter of diffusion-weighted magnetic resonance imaging: Correlation with histological microvessel density-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorHye-Jeong Lee-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorYong Eun Chung-
dc.contributor.googleauthorHyo Sub Shim-
dc.contributor.googleauthorYoung Jin Kim-
dc.contributor.googleauthorJin Hur-
dc.contributor.googleauthorYoo Jin Hong-
dc.contributor.googleauthorByoung Wook Choi-
dc.identifier.doi10.1002/mrm.24810-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03662-
dc.contributor.localIdA04059-
dc.contributor.localIdA04370-
dc.contributor.localIdA04422-
dc.contributor.localIdA02219-
dc.contributor.localIdA00727-
dc.contributor.localIdA03320-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ02179-
dc.identifier.eissn1522-2594-
dc.identifier.pmid23798038-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/mrm.24810/abstract-
dc.subject.keywordangiogenesis-
dc.subject.keyworddiffusion-weighted MRI-
dc.subject.keywordintravoxel incoherent motion-
dc.subject.keywordmicrovessel density-
dc.subject.keywordtumor-
dc.contributor.alternativeNameChung, Yong Eun-
dc.contributor.alternativeNameChoi, Byoung Wook-
dc.contributor.alternativeNameHur, Jin-
dc.contributor.alternativeNameHong, Yoo Jin-
dc.contributor.alternativeNameKim, Young Jin-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameShim, Hyo Sup-
dc.contributor.alternativeNameLee, Hye Jeong-
dc.contributor.affiliatedAuthorChung, Yong Eun-
dc.contributor.affiliatedAuthorChoi, Byoung Wook-
dc.contributor.affiliatedAuthorHur, Jin-
dc.contributor.affiliatedAuthorHong, Yoo Jin-
dc.contributor.affiliatedAuthorShim, Hyo Sup-
dc.contributor.affiliatedAuthorKim, Young Jin-
dc.contributor.affiliatedAuthorLee, Hye Jeong-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.rights.accessRightsfree-
dc.citation.volume71-
dc.citation.number4-
dc.citation.startPage1554-
dc.citation.endPage1558-
dc.identifier.bibliographicCitationMAGNETIC RESONANCE IN MEDICINE, Vol.71(4) : 1554-1558, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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