Cited 122 times in
Tumor perfusion-related parameter of diffusion-weighted magnetic resonance imaging: Correlation with histological microvessel density
DC Field | Value | Language |
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dc.contributor.author | 정용은 | - |
dc.contributor.author | 최병욱 | - |
dc.contributor.author | 허진 | - |
dc.contributor.author | 홍유진 | - |
dc.contributor.author | 김영진 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 심효섭 | - |
dc.contributor.author | 이혜정 | - |
dc.date.accessioned | 2015-01-06T16:42:14Z | - |
dc.date.available | 2015-01-06T16:42:14Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0740-3194 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98603 | - |
dc.description.abstract | PURPOSE: We obtained intravoxel incoherent motion (IVIM) parameters through biexponential analysis on diffusion-weighted MR imaging (DWI) using multiple b values. Correlation was evaluated between these parameters and histological microvessel density (MVD) for the possibility of noninvasive evaluation of MVD with DWI. METHODS: Twenty-five nude mice with the HT29 colorectal cancer cells implanted were analyzed after undergoing DWI with multiple b values (0, 50, 100, 300, 500, 700, and 1000 s/mm(2)). Tissue diffusivity (D(t)), pseudo-diffusion coefficient (D(p)), and perfusion fraction (f(p)) were calculated using a biexponential analysis, and these parameters were correlated with MVD. The MVD was determined with the CD31 stain. For statistical analysis, Spearman's rank correlation was applied. RESULTS: The mean value and correlation coefficient with MVD for each IVIM parameter were as follows: D(t) = 0.98 ± 0.06 × 10(-3) mm(2)/s with r = 0.139 (P = 0.508); D(p) = 23.70 ± 7.94 × 10(-3) mm(2)/s with r = 0.782 (P < 0.001); and f(p) = 15.58 ± 5.7% with r = 0.749 (P < 0.001). D(p) and f(p) showed significant correlation with MVD, but D(t) did not. CONCLUSION: The IVIM parameters, D(p) and f(p), on DWI might be used in the noninvasive evaluation of MVD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1554~1558 | - |
dc.relation.isPartOf | MAGNETIC RESONANCE IN MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Diffusion Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | HT29 Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Enhancement/methods | - |
dc.subject.MESH | Image Interpretation, Computer-Assisted/methods* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Microvessels/pathology* | - |
dc.subject.MESH | Neoplasms, Experimental/complications* | - |
dc.subject.MESH | Neoplasms, Experimental/pathology* | - |
dc.subject.MESH | Neovascularization, Pathologic/complications* | - |
dc.subject.MESH | Neovascularization, Pathologic/pathology* | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Statistics as Topic | - |
dc.title | Tumor perfusion-related parameter of diffusion-weighted magnetic resonance imaging: Correlation with histological microvessel density | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Hye-Jeong Lee | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Yong Eun Chung | - |
dc.contributor.googleauthor | Hyo Sub Shim | - |
dc.contributor.googleauthor | Young Jin Kim | - |
dc.contributor.googleauthor | Jin Hur | - |
dc.contributor.googleauthor | Yoo Jin Hong | - |
dc.contributor.googleauthor | Byoung Wook Choi | - |
dc.identifier.doi | 10.1002/mrm.24810 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03662 | - |
dc.contributor.localId | A04059 | - |
dc.contributor.localId | A04370 | - |
dc.contributor.localId | A04422 | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A00727 | - |
dc.contributor.localId | A03320 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J02179 | - |
dc.identifier.eissn | 1522-2594 | - |
dc.identifier.pmid | 23798038 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/mrm.24810/abstract | - |
dc.subject.keyword | angiogenesis | - |
dc.subject.keyword | diffusion-weighted MRI | - |
dc.subject.keyword | intravoxel incoherent motion | - |
dc.subject.keyword | microvessel density | - |
dc.subject.keyword | tumor | - |
dc.contributor.alternativeName | Chung, Yong Eun | - |
dc.contributor.alternativeName | Choi, Byoung Wook | - |
dc.contributor.alternativeName | Hur, Jin | - |
dc.contributor.alternativeName | Hong, Yoo Jin | - |
dc.contributor.alternativeName | Kim, Young Jin | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Shim, Hyo Sup | - |
dc.contributor.alternativeName | Lee, Hye Jeong | - |
dc.contributor.affiliatedAuthor | Chung, Yong Eun | - |
dc.contributor.affiliatedAuthor | Choi, Byoung Wook | - |
dc.contributor.affiliatedAuthor | Hur, Jin | - |
dc.contributor.affiliatedAuthor | Hong, Yoo Jin | - |
dc.contributor.affiliatedAuthor | Shim, Hyo Sup | - |
dc.contributor.affiliatedAuthor | Kim, Young Jin | - |
dc.contributor.affiliatedAuthor | Lee, Hye Jeong | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 71 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1554 | - |
dc.citation.endPage | 1558 | - |
dc.identifier.bibliographicCitation | MAGNETIC RESONANCE IN MEDICINE, Vol.71(4) : 1554-1558, 2014 | - |
dc.identifier.rimsid | 38138 | - |
dc.type.rims | ART | - |
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