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Prevalence and extent of atherosclerotic coronary artery disease and related outcome based on coronary computed tomographic angiography in asymptomatic elderly patients: retrospective cohort study

Authors
 Hye-Jeong Lee  ;  Young Jin Kim  ;  Jin Hur  ;  Ji Won Lee  ;  Yoo Jin Hong  ;  Hee Yeong Kim  ;  Hyuk-Jae Chang  ;  Tae Hoon Kim  ;  Byoung Wook Choi 
Citation
 INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Vol.30(3) : 669-676, 2014 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING 
ISSN
 1569-5794 
Issue Date
2014
MeSH
Aged ; Cohort Studies ; Comorbidity ; Coronary Angiography/methods* ; Coronary Artery Disease/diagnostic imaging* ; Coronary Artery Disease/epidemiology* ; Coronary Artery Disease/therapy ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/epidemiology ; Coronary Stenosis/therapy ; Female ; Follow-Up Studies ; Geriatric Assessment/methods ; Geriatric Assessment/statistics & numerical data ; Humans ; Image Processing, Computer-Assisted/methods ; Kaplan-Meier Estimate ; Male ; Patient Outcome Assessment* ; Plaque, Atherosclerotic/diagnostic imaging ; Plaque, Atherosclerotic/epidemiology ; Plaque, Atherosclerotic/therapy ; Prevalence ; Retrospective Studies ; Risk Factors ; Tomography, X-Ray Computed/methods*
Keywords
Elderly patient ; Old patient ; Coronary artery disease ; Coronary CT angiography ; Outcome
Abstract
There is little data regarding coronary artery disease (CAD) and/or atherosclerotic plaques on coronary computed tomographic angiography (CCTA) among the elderly and its outcome, especially in asymptomatic patients. Using CCTA, we evaluated the prevalence and extent of CAD and/or atherosclerosis and related outcomes in asymptomatic elderly patients as compared with symptomatic elderly patients. The study included 1,196 consecutive patients aged 70 years or older who underwent CCTA over a 2-year period. Data were retrospectively evaluated for clinical cardiovascular risk factors with co-morbidities, and CCTA findings, including calcium scores, atherosclerotic plaques (number, plaque-segment score, plaque-extent score, and plaque-significant score) and presence of significant CAD. Follow-up data for active management and all-cause mortality after CCTA were collected for 2 years. Two-sided Student’s t test for independent samples, Chi square contingency tables, and Kaplan–Meier survival curves were used for statistical analysis. Data for 454 asymptomatic and 742 symptomatic elderly patients were analyzed. The prevalence of significant CAD and the extent of atherosclerotic plaques did not differ between the two groups (all P > 0.05). Asymptomatic patients with significant CAD on CCTA, were less likely to receive active management (P < 0.001), which may be related to the higher death rate in this group (P = 0.012) than in the symptomatic patients with significant CAD. Overall, symptoms were not related to the presence of significant CAD or to the extent of atherosclerosis in these elderly patients. However, all-cause mortality was higher in the asymptomatic patients with significant CAD than in the symptomatic ones
Full Text
http://link.springer.com/article/10.1007%2Fs10554-014-0366-3
DOI
10.1007/s10554-014-0366-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Kim, Tae Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-3598-2529
Kim, Hee Yeong(김희영)
Lee, Ji Won(이지원)
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
Hong, Yoo Jin(홍유진) ORCID logo https://orcid.org/0000-0002-7276-0944
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98601
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