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Effect of the interaction between periodontitis and type 1 diabetes mellitus on alveolar bone, mandibular condyle and tibia

Authors
 Ji-Hye Kim  ;  Dong-Eun Lee  ;  K. S. Niluka Darshani Gunawardhana  ;  Seong-Ho Choi  ;  Gye-Hyeong Woo  ;  Jeong-Heon Cha  ;  Eun-Jung Bak  ;  Yun-Jung Yoo 
Citation
 ACTA ODONTOLOGICA SCANDINAVICA, Vol.72(4) : 265-273, 2014 
Journal Title
 ACTA ODONTOLOGICA SCANDINAVICA 
ISSN
 0001-6357 
Issue Date
2014
MeSH
Base Sequence ; DNA Primers ; Diabetes Mellitus, Type 1/complications* ; Diabetes Mellitus, Type 1/pathology ; Humans ; Mandibular Condyle/pathology* ; Periodontitis/complications* ; Periodontitis/pathology ; Real-Time Polymerase Chain Reaction ; Tibia/pathology* ; X-Ray Microtomography
Keywords
Bone ; periodontitis ; type 1 diabetes mellitus
Abstract
OBJECTIVE: This study examined the effect of the interaction between periodontitis and type 1 diabetes mellitus on alveolar bone, mandibular condyle and tibia in animal models. MATERIALS AND METHODS: Rats were divided into normal, periodontitis, diabetic and diabetic with periodontitis groups. After injection of streptozotocin to induce diabetes, periodontitis was induced by ligation of both lower-side first molars for 30 days. Alveolar bone loss and trabecular bone volume fraction (BVF) of the mandibular condyle and tibia were estimated via hematoxylin and eosin staining and micro-computed tomography, respectively. Osteoclastogenesis of bone marrow cells isolated from tibia and femur was assayed using tartrate-resistant acid phosphatase staining. RESULTS: The cemento-enamel junction to the alveolar bone crest distance and ratio of periodontal ligament area in the diabetic with periodontitis group were significantly increased compared to those of the periodontitis group. Mandibular condyle BVF did not differ among groups. The BVF of tibia in the diabetic and diabetic with periodontitis groups was lower than that of the normal and periodontitis groups. Osteoclastogenesis of bone marrow cells in the diabetic groups was higher than that in the non-diabetic groups. However, the BVF of tibia and osteoclastogenesis in the diabetic with periodontitis group were not significantly different than those in the diabetic group. CONCLUSIONS: Type 1 diabetes mellitus aggravates alveolar bone loss induced by periodontitis, but periodontitis does not alter the mandibular condyle and tibia bone loss induced by diabetes. Alveolar bone, mandibular condyle and tibia may have different responses to bone loss stimuli in the diabetic environment.
Full Text
http://informahealthcare.com/doi/abs/10.3109/00016357.2013.822551
DOI
10.3109/00016357.2013.822551
Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ji Hye(김지혜)
Gunawardhana, K. S. Niluka Darshani(니루카)
Bak, Eun-Jung(박은정) ORCID logo https://orcid.org/0000-0002-7976-8594
Yoo, Yun Jung(유윤정) ORCID logo https://orcid.org/0000-0002-0045-9597
Lee, Dong Eun(이동은)
Cha, Jung Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98564
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