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The Relationship among Complex Fractionated Electrograms, Wavebreak, Phase Singularity, and Local Dominant Frequency in Fibrillation Wave-Dynamics: a Modeling Comparison Study

Authors
 Yonghyeon Yun  ;  Minki Hwang  ;  Jae Hyung Park  ;  Hangsik Shin  ;  Eun Bo Shim  ;  Hui-Nam Pak 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.29(3) : 370-377, 2014 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2014
MeSH
Algorithms ; Atrial Fibrillation/physiopathology* ; Body Surface Potential Mapping ; Catheter Ablation ; Electrocardiography* ; Electrodes ; Heart Atria/physiopathology ; Humans ; Models, Biological*
Keywords
Complex Fractionated Electrogram ; Fibrillation ; Simulation Modeling
Abstract
Although complex fractionated electrogram (CFE) is known to be a target for catheter ablation of fibrillation, its physiological meaning in fibrillation wave-dynamics remains to be clarified. We evaluated the spatiotemporal relationships among the parameters of fibrillation wave-dynamics by simulation modeling. We generated maps of CFE-cycle length (CFE-CL), local dominant frequency (LDF), wave break (WB), and phase singularity (PS) of fibrillation in 2-dimensional homogeneous bidomain cardiac modeling (1,000 × 1,000 cells ten Tusscher model). We compared spatiotemporal correlations by dichotomizing each maps into 10 × 10 lattice zones. In spatial distribution, WB and PS showed excellent correlation (R = 0.963, P < 0.001). CFE-CL had weak correlations with WB (R = 0.288, P < 0.001), PS (R = 0.313, P < 0.001), and LDF (R = -0.411, P < 0.001). However, LDF did not show correlation with PS or WB. PSs were mostly distributed at the periphery of low CFE-CL area. Virtual ablation (5% of critical mass) of CFE-CL < 100 ms terminated fibrillation at 14.3 sec, and high LDF ablation (5% of critical mass) changed fibrillation to organized tachycardia, respectively. In homogeneous 2D fibrillation modeling, CFE-CL was weakly correlated with WB, PS, and LDF, spatiotemporally. PSs are mostly positioned at the periphery of low CFE-CL areas, and virtual ablation targeting low CFE-CL regions terminated fibrillation successfully.
Files in This Item:
T201400969.pdf Download
DOI
10.3346/jkms.2014.29.3.370
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Park, Jae Hyung(박재형)
Pak, Hui Nam(박희남) ORCID logo https://orcid.org/0000-0002-3256-3620
Hwang, Min Ki(황민기)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98498
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