Cited 9 times in
The Relationship among Complex Fractionated Electrograms, Wavebreak, Phase Singularity, and Local Dominant Frequency in Fibrillation Wave-Dynamics: a Modeling Comparison Study
DC Field | Value | Language |
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dc.contributor.author | 박재형 | - |
dc.contributor.author | 박희남 | - |
dc.contributor.author | 황민기 | - |
dc.date.accessioned | 2015-01-06T16:38:58Z | - |
dc.date.available | 2015-01-06T16:38:58Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98498 | - |
dc.description.abstract | Although complex fractionated electrogram (CFE) is known to be a target for catheter ablation of fibrillation, its physiological meaning in fibrillation wave-dynamics remains to be clarified. We evaluated the spatiotemporal relationships among the parameters of fibrillation wave-dynamics by simulation modeling. We generated maps of CFE-cycle length (CFE-CL), local dominant frequency (LDF), wave break (WB), and phase singularity (PS) of fibrillation in 2-dimensional homogeneous bidomain cardiac modeling (1,000 × 1,000 cells ten Tusscher model). We compared spatiotemporal correlations by dichotomizing each maps into 10 × 10 lattice zones. In spatial distribution, WB and PS showed excellent correlation (R = 0.963, P < 0.001). CFE-CL had weak correlations with WB (R = 0.288, P < 0.001), PS (R = 0.313, P < 0.001), and LDF (R = -0.411, P < 0.001). However, LDF did not show correlation with PS or WB. PSs were mostly distributed at the periphery of low CFE-CL area. Virtual ablation (5% of critical mass) of CFE-CL < 100 ms terminated fibrillation at 14.3 sec, and high LDF ablation (5% of critical mass) changed fibrillation to organized tachycardia, respectively. In homogeneous 2D fibrillation modeling, CFE-CL was weakly correlated with WB, PS, and LDF, spatiotemporally. PSs are mostly positioned at the periphery of low CFE-CL areas, and virtual ablation targeting low CFE-CL regions terminated fibrillation successfully. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 370~377 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Algorithms | - |
dc.subject.MESH | Atrial Fibrillation/physiopathology* | - |
dc.subject.MESH | Body Surface Potential Mapping | - |
dc.subject.MESH | Catheter Ablation | - |
dc.subject.MESH | Electrocardiography* | - |
dc.subject.MESH | Electrodes | - |
dc.subject.MESH | Heart Atria/physiopathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Models, Biological* | - |
dc.title | The Relationship among Complex Fractionated Electrograms, Wavebreak, Phase Singularity, and Local Dominant Frequency in Fibrillation Wave-Dynamics: a Modeling Comparison Study | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Cardiovascular Research Institute (심혈관연구소) | - |
dc.contributor.googleauthor | Yonghyeon Yun | - |
dc.contributor.googleauthor | Minki Hwang | - |
dc.contributor.googleauthor | Jae Hyung Park | - |
dc.contributor.googleauthor | Hangsik Shin | - |
dc.contributor.googleauthor | Eun Bo Shim | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.identifier.doi | 10.3346/jkms.2014.29.3.370 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01639 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A04459 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 24616586 | - |
dc.subject.keyword | Complex Fractionated Electrogram | - |
dc.subject.keyword | Fibrillation | - |
dc.subject.keyword | Simulation Modeling | - |
dc.contributor.alternativeName | Park, Jae Hyung | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Hwang, Min Ki | - |
dc.contributor.affiliatedAuthor | Park, Jae Hyung | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Hwang, Min Ki | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 370 | - |
dc.citation.endPage | 377 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.29(3) : 370-377, 2014 | - |
dc.identifier.rimsid | 57628 | - |
dc.type.rims | ART | - |
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