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The distribution of cerebral microbleeds determines their association with arterial stiffness in non-cardioembolic acute stroke patients

Authors
 T.-J. Song  ;  J. Kim  ;  Y. D. Kim  ;  H. S. Nam  ;  H. S. Lee  ;  C. M. Nam  ;  J. H. Heo 
Citation
 EUROPEAN JOURNAL OF NEUROLOGY, Vol.21(3) : 463-469, 2014 
Journal Title
 EUROPEAN JOURNAL OF NEUROLOGY 
ISSN
 1351-5101 
Issue Date
2014
MeSH
Aged ; Aged, 80 and over ; Analysis of Variance ; Brain/pathology* ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/etiology* ; Female ; Humans ; Intracranial Arteriosclerosis/diagnosis ; Intracranial Arteriosclerosis/etiology* ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Stroke/complications* ; Stroke/diagnostic imaging ; Ultrasonography, Doppler, Transcranial ; Vascular Stiffness/physiology*
Keywords
arterial stiffness ; cerebral amyloid angiopathy ; cerebral microbleeds
Abstract
BACKGROUND AND PURPOSE: Increased arterial stiffness causes vessel damage in the end-organs. Therefore small vessels in the brain may be susceptible to increased arterial stiffness. Cerebral microbleeds (CMBs) are topographically or pathophysiologically categorized as deep or infratentorial type and strictly lobar type. Whether the presence and location of CMBs are associated with brachial-ankle pulse wave velocity (baPWV) which represents a measure of arterial stiffness was investigated. METHODS: Between June 2006 and January 2012, 1137 consecutive patients diagnosed with non-cardioembolic acute ischaemic stroke and who underwent baPWV measurement and brain gradient-echo imaging were enrolled. CMBs were classified as deep or infratentorial or strictly lobar according to their location. Severity of leukoaraiosis was determined using the Fazekas scoring system. RESULTS: CMBs were found in 30.7% of the included patients. These patients were older than those without CMBs. Mean baPWV was higher in patients with CMBs than in those without (20 ± 5 m/s vs. 19 ± 5 m/s; P = 0.001). When comparing baPWV according to the location of the CMB, it was higher in the deep or infratentorial CMB group than in the strictly lobar CMB group (22 ± 5 m/s vs. 20 ± 5 m/s; P = 0.001). In univariate and multivariate multinomial logistic regression analyses, baPWV was found to be independently associated with deep or infratentorial CMBs. CONCLUSIONS: Arterial stiffness was independently associated with deep or infratentorial CMBs but not lobar CMBs. These findings suggest a pathophysiological association between arterial stiffness and CMBs in the deep or infratentorial region.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/ene.12332/abstract
DOI
10.1111/ene.12332
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Kim, Jinkwon(김진권) ORCID logo https://orcid.org/0000-0003-0156-9736
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Song, Tae Jin(송태진)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98412
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