Cited 40 times in
The distribution of cerebral microbleeds determines their association with arterial stiffness in non-cardioembolic acute stroke patients
DC Field | Value | Language |
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dc.contributor.author | 남정모 | - |
dc.contributor.author | 남효석 | - |
dc.contributor.author | 송태진 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 허지회 | - |
dc.contributor.author | 김영대 | - |
dc.contributor.author | 김진권 | - |
dc.date.accessioned | 2015-01-06T16:36:10Z | - |
dc.date.available | 2015-01-06T16:36:10Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1351-5101 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98412 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: Increased arterial stiffness causes vessel damage in the end-organs. Therefore small vessels in the brain may be susceptible to increased arterial stiffness. Cerebral microbleeds (CMBs) are topographically or pathophysiologically categorized as deep or infratentorial type and strictly lobar type. Whether the presence and location of CMBs are associated with brachial-ankle pulse wave velocity (baPWV) which represents a measure of arterial stiffness was investigated. METHODS: Between June 2006 and January 2012, 1137 consecutive patients diagnosed with non-cardioembolic acute ischaemic stroke and who underwent baPWV measurement and brain gradient-echo imaging were enrolled. CMBs were classified as deep or infratentorial or strictly lobar according to their location. Severity of leukoaraiosis was determined using the Fazekas scoring system. RESULTS: CMBs were found in 30.7% of the included patients. These patients were older than those without CMBs. Mean baPWV was higher in patients with CMBs than in those without (20 ± 5 m/s vs. 19 ± 5 m/s; P = 0.001). When comparing baPWV according to the location of the CMB, it was higher in the deep or infratentorial CMB group than in the strictly lobar CMB group (22 ± 5 m/s vs. 20 ± 5 m/s; P = 0.001). In univariate and multivariate multinomial logistic regression analyses, baPWV was found to be independently associated with deep or infratentorial CMBs. CONCLUSIONS: Arterial stiffness was independently associated with deep or infratentorial CMBs but not lobar CMBs. These findings suggest a pathophysiological association between arterial stiffness and CMBs in the deep or infratentorial region. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 463~469 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Brain/pathology* | - |
dc.subject.MESH | Cerebral Hemorrhage/diagnostic imaging | - |
dc.subject.MESH | Cerebral Hemorrhage/etiology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intracranial Arteriosclerosis/diagnosis | - |
dc.subject.MESH | Intracranial Arteriosclerosis/etiology* | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Stroke/complications* | - |
dc.subject.MESH | Stroke/diagnostic imaging | - |
dc.subject.MESH | Ultrasonography, Doppler, Transcranial | - |
dc.subject.MESH | Vascular Stiffness/physiology* | - |
dc.title | The distribution of cerebral microbleeds determines their association with arterial stiffness in non-cardioembolic acute stroke patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | T.-J. Song | - |
dc.contributor.googleauthor | J. Kim | - |
dc.contributor.googleauthor | Y. D. Kim | - |
dc.contributor.googleauthor | H. S. Nam | - |
dc.contributor.googleauthor | H. S. Lee | - |
dc.contributor.googleauthor | C. M. Nam | - |
dc.contributor.googleauthor | J. H. Heo | - |
dc.identifier.doi | 10.1111/ene.12332 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01264 | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A02073 | - |
dc.contributor.localId | A04369 | - |
dc.contributor.localId | A00702 | - |
dc.contributor.localId | A01012 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J00830 | - |
dc.identifier.eissn | 1468-1331 | - |
dc.identifier.pmid | 24330330 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/ene.12332/abstract | - |
dc.subject.keyword | arterial stiffness | - |
dc.subject.keyword | cerebral amyloid angiopathy | - |
dc.subject.keyword | cerebral microbleeds | - |
dc.contributor.alternativeName | Nam, Jung Mo | - |
dc.contributor.alternativeName | Nam, Hyo Suk | - |
dc.contributor.alternativeName | Song, Tae Jin | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.alternativeName | Kim, Young Dae | - |
dc.contributor.alternativeName | Kim, Jin Kwon | - |
dc.contributor.affiliatedAuthor | Nam, Jung Mo | - |
dc.contributor.affiliatedAuthor | Nam, Hyo Suk | - |
dc.contributor.affiliatedAuthor | Song, Tae Jin | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Kim, Young Dae | - |
dc.contributor.affiliatedAuthor | Kim, Jin Kwon | - |
dc.contributor.affiliatedAuthor | Lee, Hye Sun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 21 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 463 | - |
dc.citation.endPage | 469 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NEUROLOGY, Vol.21(3) : 463-469, 2014 | - |
dc.identifier.rimsid | 56585 | - |
dc.type.rims | ART | - |
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