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Osteoconductivity and biodegradation of synthetic bone substitutes with different tricalcium phosphate contents in rabbits

Authors
 Cheryl Yang  ;  Otgonbayar Unursaikhan  ;  Jung-Seok Lee  ;  Ui-Won Jung  ;  Chang-Sung Kim  ;  Seong-Ho Choi 
Citation
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol.102B(1) : 80-88, 2014 
Journal Title
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 
ISSN
 1552-4973 
Issue Date
2014
MeSH
Absorbable Implants ; Animals ; Bone Regeneration ; Bone Substitutes/chemistry* ; Bone Substitutes/metabolism ; Calcium Phosphates/chemistry* ; Calcium Phosphates/metabolism ; Humans ; Male ; Materials Testing ; Microscopy, Electron, Scanning ; Osseointegration ; Rabbits ; Skull/anatomy & histology ; Skull/physiology ; Skull/surgery
Keywords
beta tricalcium phosphate ; biodegradation ; bone regeneration ; hydroxyapatite ; synthetic bone graft
Abstract
Various synthetic bone substitutes have been developed to reconstruct the bony defects that clinicians often encounter during surgical procedures. Among various synthetic bone substitutes, calcium phosphate (Ca-P) ceramics have been investigated because their composition and structure are similar to those of human bone. We evaluated the bone healing and biodegradation patterns of three types of Ca-P ceramic particle with various hydroxyapatite (HA)/β-tricalcium phosphate (β-TCP) weight ratio: pure β-TCP, biphasic Ca-P (BCP) with a HA/β-TCP weight ratio of 60/40 (BCP 60/40), and BCP with an HA/β-TCP weight ratio of 20/80 (BCP 20/80). Four 8-mm-diameter defects were created in ten rabbits. Three of the defects in each rabbit were separately and randomly filled with one of the three experimental Ca-P ceramic particles, and the fourth was filled with blood clots (control). The specimens were harvested at 2 and 8 weeks post-surgery. The histologic and histometric findings revealed that the augmented space and new bone formation were significantly better for all three Ca-P ceramics than for the control group at both 2 and 8 weeks (p < 0.05). Compared to the pure β-TCP, the two BCP groups were found to provide a larger amount of newly formed bone and bone density at the 2- and 8-week post-operative periods (p < 0.05). Throughout the observation period, BCP 60/40 and BCP 20/80 exhibited a similar bone healing and biodegradation patterns with regard to both individual particles and the total augmented area in vivo.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.32984/abstract
DOI
10.1002/jbm.b.32984
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Unursaikhan, Otgonbayar(어운희)
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98396
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