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Efficacy of IP-10 as a biomarker for monitoring tuberculosis teratment

Authors
 Ji Young Hong  ;  Hye Jon Lee  ;  Song Yee Kim  ;  Kyung Soo Chung  ;  Eun Young Kim  ;  Ji Ye Jung  ;  Moo Suk Park  ;  Young Sam Kim  ;  Se Kyu Kim  ;  Joon Chang  ;  Sang-Nae Cho  ;  Young Ae Kang 
Citation
 Journal of Infection, Vol.68(3) : 252-258, 2014 
Journal Title
 Journal of Infection 
ISSN
 0163-4453 
Issue Date
2014
Abstract
OBJECTIVES: IP-10 has been proposed as a promising alternative marker for the diagnosis of tuberculosis (TB). METHODS: In this exploratory study, we assessed the levels of serum IP-10 and TB antigen-dependent IP-10 at the time of diagnosis and after completing treatment in 32 patients with active TB. RESULTS: Significant changes in concentration between the time of diagnosis and the completion of therapy were observed for serum IP-10 (P < 0.001; median: 140.4 and 105.7 pg/ml, respectively) and TB antigen-dependent IP-10 (P = 0.002; median: 20,000 and 13,720 pg/ml, respectively). The proportion of TB antigen-dependent IP-10 responders did not change significantly between baseline and the completion of therapy (P = 0.35), whereas the proportion of serum IP-10 responders was significantly different (P = 0.001). CONCLUSIONS: Serum IP-10 and TB antigen-dependent IP-10 responses to QFT-GIT antigens might be a useful biomarker for monitoring the efficacy of therapy in patients with active TB.
Full Text
http://www.sciencedirect.com/science/article/pii/S0163445313003368
DOI
10.1016/j.jinf.2013.09.033
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실)
Yonsei Authors
강영애(Kang, Young Ae) ORCID logo https://orcid.org/0000-0002-7783-5271
김세규(Kim, Se Kyu)
김송이(Kim, Song Yee) ORCID logo https://orcid.org/0000-0001-8627-486X
김영삼(Kim, Young Sam) ORCID logo https://orcid.org/0000-0001-9656-8482
김은영(Kim, Eun Young)
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
장준(Chang, Joon)
정경수(Jung, Kyung Soo) ORCID logo https://orcid.org/0000-0003-1604-8730
정지예(Jung, Ji Ye) ORCID logo https://orcid.org/0000-0003-1589-4142
조상래(Cho, Sang Nae)
홍지영(Hong , Ji Young)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98390
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