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Efficacy of IP-10 as a biomarker for monitoring tuberculosis teratment

Authors
 Ji Young Hong  ;  Hye Jon Lee  ;  Song Yee Kim  ;  Kyung Soo Chung  ;  Eun Young Kim  ;  Ji Ye Jung  ;  Moo Suk Park  ;  Young Sam Kim  ;  Se Kyu Kim  ;  Joon Chang  ;  Sang-Nae Cho  ;  Young Ae Kang 
Citation
 Journal of Infection, Vol.68(3) : 252-258, 2014 
Journal Title
 Journal of Infection 
ISSN
 0163-4453 
Issue Date
2014
MeSH
Adult ; Aged ; Biomarkers/blood* ; Chemokine CXCL10/blood* ; Drug Monitoring ; Female ; Humans ; Interferon-gamma/blood ; Longitudinal Studies ; Male ; Middle Aged ; Tuberculosis/blood ; Tuberculosis/diagnosis* ; Tuberculosis/drug therapy* ; Tuberculosis/immunology
Keywords
IP-10 ; Monitoring ; Tuberculosis
Abstract
OBJECTIVES: IP-10 has been proposed as a promising alternative marker for the diagnosis of tuberculosis (TB). METHODS: In this exploratory study, we assessed the levels of serum IP-10 and TB antigen-dependent IP-10 at the time of diagnosis and after completing treatment in 32 patients with active TB. RESULTS: Significant changes in concentration between the time of diagnosis and the completion of therapy were observed for serum IP-10 (P < 0.001; median: 140.4 and 105.7 pg/ml, respectively) and TB antigen-dependent IP-10 (P = 0.002; median: 20,000 and 13,720 pg/ml, respectively). The proportion of TB antigen-dependent IP-10 responders did not change significantly between baseline and the completion of therapy (P = 0.35), whereas the proportion of serum IP-10 responders was significantly different (P = 0.001). CONCLUSIONS: Serum IP-10 and TB antigen-dependent IP-10 responses to QFT-GIT antigens might be a useful biomarker for monitoring the efficacy of therapy in patients with active TB.
Full Text
http://www.sciencedirect.com/science/article/pii/S0163445313003368
DOI
10.1016/j.jinf.2013.09.033
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Se Kyu(김세규)
Kim, Song Yee(김송이) ORCID logo https://orcid.org/0000-0001-8627-486X
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Eun Young(김은영) ORCID logo https://orcid.org/0000-0002-3281-5744
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Jung, Kyung Soo(정경수) ORCID logo https://orcid.org/0000-0003-1604-8730
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
Cho, Sang Nae(조상래)
Hong , Ji Young(홍지영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98390
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