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Treatment of FGF-2 onstem cells from inflamed dental pulp tissue from human deciduous teeth

DC Field Value Language
dc.contributor.author김성환-
dc.contributor.author김창성-
dc.contributor.author박정철-
dc.contributor.author송제선-
dc.contributor.author조규성-
dc.contributor.author최은영-
dc.date.accessioned2015-01-06T16:27:50Z-
dc.date.available2015-01-06T16:27:50Z-
dc.date.issued2014-
dc.identifier.issn1354-523X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98152-
dc.description.abstractOBJECTIVE: The purposes of this study were to isolate and characterize stem cells from inflamed pulp tissue of human functional deciduous teeth (iSHFD) and to evaluate the influence of fibroblastic growth factor-2 (FGF-2) on the regenerative potential. MATERIALS AND METHODS: We successfully isolated mesenchymal stem cells (MSCs) from the inflamed dental pulp tissue of human deciduous teeth and demonstrated that their regenerative potential could be enhanced by the application of FGF-2 (20 ng ml(-1)) during ex vivo expansion. Isolated stem cells expanded in FGF-2 were characterized using a colony-forming assay, proliferation, migration, in vitro differentiation, in vivo ectopic transplantation assay, and gene expression profiling. RESULTS: MSCs isolated from the inflamed pulp tissue of functional deciduous teeth potentially possess the qualities of those from human exfoliated deciduous teeth. FGF-2 applied to iSHFD during expansion enhanced the colony-forming efficiency of these cells, increased their proliferation and migration potential, and reduced their differentiation potential in vitro. However, the ectopic transplantation of iSHFD/FGF-2 in vivo increased the formation of dentin-like material. CONCLUSION: FGF-2 expansion of stem cells from inflamed pulp tissues of human deciduous teeth can be a good source of stem cells for future clinical applications and a novel way of using discarded inflamed tissues.-
dc.description.statementOfResponsibilityopen-
dc.format.extent191~204-
dc.relation.isPartOfORAL DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCell Differentiation-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDental Pulp/cytology*-
dc.subject.MESHFibroblast Growth Factor 2/pharmacology-
dc.subject.MESHFibroblast Growth Factor 2/physiology*-
dc.subject.MESHHumans-
dc.subject.MESHMesenchymal Stromal Cells/cytology*-
dc.subject.MESHMesenchymal Stromal Cells/drug effects-
dc.subject.MESHMesenchymal Stromal Cells/physiology*-
dc.subject.MESHPulpitis/pathology*-
dc.subject.MESHTooth, Deciduous-
dc.titleTreatment of FGF-2 onstem cells from inflamed dental pulp tissue from human deciduous teeth-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Pediatric Dentistry (소아치과학)-
dc.contributor.googleauthorJC Kim-
dc.contributor.googleauthorJ-C Park-
dc.contributor.googleauthorS-H Kim-
dc.contributor.googleauthorG-I Im-
dc.contributor.googleauthorB-S Kim-
dc.contributor.googleauthorJ-B Lee-
dc.contributor.googleauthorE-Y Choi-
dc.contributor.googleauthorJ-S Song-
dc.contributor.googleauthorK-S Cho-
dc.contributor.googleauthorC-S Kim-
dc.identifier.doi10.1111/odi.12089-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00593-
dc.contributor.localIdA01041-
dc.contributor.localIdA01653-
dc.contributor.localIdA02058-
dc.contributor.localIdA03810-
dc.contributor.localIdA04155-
dc.relation.journalcodeJ02438-
dc.identifier.eissn1601-0825-
dc.identifier.pmid23496287-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/odi.12089/abstract-
dc.subject.keywordbiomedical engineering-
dc.subject.keywordinflammatory/immune response and modulation-
dc.subject.keywordmesenchymal stem cells-
dc.subject.keywordtissue development and growth-
dc.contributor.alternativeNameKim, Sung Whan-
dc.contributor.alternativeNameKim, Chang Sung-
dc.contributor.alternativeNamePark, Jung Chul-
dc.contributor.alternativeNameSong, Je Seon-
dc.contributor.alternativeNameCho, Kyoo Sung-
dc.contributor.alternativeNameChoi, Eun Young-
dc.contributor.affiliatedAuthorKim, Sung Whan-
dc.contributor.affiliatedAuthorKim, Chang Sung-
dc.contributor.affiliatedAuthorPark, Jung Chul-
dc.contributor.affiliatedAuthorSong, Je Seon-
dc.contributor.affiliatedAuthorCho, Kyoo Sung-
dc.contributor.affiliatedAuthorChoi, Eun Young-
dc.rights.accessRightsfree-
dc.citation.volume20-
dc.citation.number2-
dc.citation.startPage191-
dc.citation.endPage204-
dc.identifier.bibliographicCitationORAL DISEASES, Vol.20(2) : 191-204, 2014-
dc.identifier.rimsid50683-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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