Cited 11 times in
Predominance of small dense LDL differentiates metabolically unhealthy from metabolically healthy overweight adults in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 김수 | - |
dc.contributor.author | 이덕철 | - |
dc.contributor.author | 이지원 | - |
dc.contributor.author | 이향규 | - |
dc.date.accessioned | 2015-01-06T16:26:24Z | - |
dc.date.available | 2015-01-06T16:26:24Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98108 | - |
dc.description.abstract | OBJECTIVE: The purposes of this study were (1) to determine the association between lipoprotein subfraction profiles and metabolically healthy overweight (MHO) phenotype, as defined by visceral adiposity; and (2) to identify the strongest predictor of metabolic health among the lipoprotein measurements. MATERIALS/METHODS: This cross-sectional study was comprised of 462 overweight patients, who were classified as MHO or non-MHO based on their visceral adipose tissue (VAT) area to subcutaneous adipose tissue area (SAT) ratio (VAT/SAT ratio). Serum lipoprotein subfraction analyses and other metabolic parameters were measured. RESULTS: Among the overweight participants, two hundred fifty-five individuals (53.7%) had the MHO phenotype. After adjusting for age, sex, medication, lifestyle factors, and confounding metabolic characteristics, the non-MHO group showed significantly higher lipid levels and a greater prevalence of unfavorable lipid profiles. LDL subclass pattern type B was the most significant predictor of the non-MHO phenotype (odds ratio 2.70; 95% CI 1.55-4.69), while serum LDL cholesterol level was not a significant predictor of the non-MHO phenotype. CONCLUSIONS: Lipoprotein subfraction particle measurements were significantly associated with the non-MHO phenotype and a higher VAT/SAT ratio, with small dense LDL predominance being the most significant predictor of MHO phenotype. These findings will help identify MHO and non-MHO phenotypes and perhaps lead to a development of cost-effective individualized treatments. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 415~421 | - |
dc.relation.isPartOf | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiposity/physiology | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intra-Abdominal Fat/metabolism | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Lipoproteins/metabolism | - |
dc.subject.MESH | Lipoproteins, LDL/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Obesity/blood | - |
dc.subject.MESH | Obesity/metabolism* | - |
dc.subject.MESH | Overweight/blood* | - |
dc.subject.MESH | Overweight/metabolism* | - |
dc.title | Predominance of small dense LDL differentiates metabolically unhealthy from metabolically healthy overweight adults in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학) | - |
dc.contributor.googleauthor | Sue Kim | - |
dc.contributor.googleauthor | Hyangkyu Lee | - |
dc.contributor.googleauthor | Duk-Chul Lee | - |
dc.contributor.googleauthor | Hye-Sun Lee | - |
dc.contributor.googleauthor | Ji-Won Lee | - |
dc.identifier.doi | 10.1016/j.metabol.2013.11.015 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02716 | - |
dc.contributor.localId | A03282 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A00628 | - |
dc.contributor.localId | A03203 | - |
dc.relation.journalcode | J02223 | - |
dc.identifier.eissn | 1532-8600 | - |
dc.identifier.pmid | 24369917 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0026049513003983 | - |
dc.subject.keyword | Lipoprotein subfraction | - |
dc.subject.keyword | Overweight | - |
dc.subject.keyword | Small dense low-density lipoprotein (LDL) | - |
dc.subject.keyword | Visceral to subcutaneous adipose tissue ratio (VAT/SAT ratio) | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.alternativeName | Kim, Sue | - |
dc.contributor.alternativeName | Lee, Duk Chul | - |
dc.contributor.alternativeName | Lee, Ji Won | - |
dc.contributor.alternativeName | Lee, Hyang Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Duk Chul | - |
dc.contributor.affiliatedAuthor | Lee, Hyang Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Hye Sun | - |
dc.contributor.affiliatedAuthor | Kim, Sue | - |
dc.contributor.affiliatedAuthor | Lee, Ji Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 63 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 415 | - |
dc.citation.endPage | 421 | - |
dc.identifier.bibliographicCitation | METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.63(3) : 415-421, 2014 | - |
dc.identifier.rimsid | 54893 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.