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Long-term Statin Therapy Improves Oncological Outcome After Radical Gastrectomy for Stage II and III Gastric Cancer

Authors
 DONG HYUK NAM  ;  HYUK LEE  ;  JUN CHUL PARK  ;  SUNG KWAN SHIN  ;  SANG KIL LEE  ;  WOO JIN HYUNG  ;  YONG CHAN LEE  ;  MIN WOONG KANG  ;  SUNG HOON NOH 
Citation
 ANTICANCER RESEARCH, Vol.34(1) : 355-361, 2014 
Journal Title
 ANTICANCER RESEARCH 
ISSN
 0250-7005 
Issue Date
2014
MeSH
Adenocarcinoma/mortality* ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Aged ; Carcinoma, Signet Ring Cell/mortality* ; Carcinoma, Signet Ring Cell/pathology ; Carcinoma, Signet Ring Cell/therapy ; Female ; Follow-Up Studies ; Gastrectomy/mortality* ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use* ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Stomach Neoplasms/mortality* ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy ; Survival Rate
Keywords
Gastric cancer ; radical gastrectomy ; statin therapy
Abstract
Background/Aim: Although several epidemiological studies have indicated that statins may have antitumor properties, the effect of statins on patient survival after curative resection of gastric cancer is unknown. The aim of the present study was to determine whether statin use could improve long-term outcomes after radical gastrectomy. Patiens and Methods: We conducted a matched case–control study of 65 statin users and 176 non-users who underwent radical gastrectomy for stage II and III gastric cancer from January 2006 to December 2009. Results: No significant differences were found in recurrence-free survival (RFS) or overall survival (OS) between statin users and non-users. However, subgroup analysis showed that patients who used statins for more than six months had more favorable outcomes than non-users or those who used statins for less than six months [adjusted hazard ratio of death (non-users as reference); statin use <6 months: 2.405, 95% confidence interval (CI)=1.056-5.477 and statin use >6 months: 0.168, 95% CI=0.032-0.881, p=0.006]. Conclusion: Statin use did not improve RFS or OS after curative resection of stage II or III gastric cancer in the overall study population. However, statin use of more than six months was associated with increased survival.
Full Text
http://ar.iiarjournals.org/content/34/1/355.long
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Min Woong(강민웅)
Nam, Dong Hyuk(남동혁)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Park, Jun Chul(박준철) ORCID logo https://orcid.org/0000-0001-8018-0010
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Lee, Hyuk(이혁)
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98060
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