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Long-term Statin Therapy Improves Oncological Outcome After Radical Gastrectomy for Stage II and III Gastric Cancer
DC Field | Value | Language |
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dc.contributor.author | 노성훈 | - |
dc.contributor.author | 박준철 | - |
dc.contributor.author | 신성관 | - |
dc.contributor.author | 이상길 | - |
dc.contributor.author | 이용찬 | - |
dc.contributor.author | 이혁 | - |
dc.contributor.author | 형우진 | - |
dc.contributor.author | 강민웅 | - |
dc.contributor.author | 남동혁 | - |
dc.date.accessioned | 2015-01-06T16:24:52Z | - |
dc.date.available | 2015-01-06T16:24:52Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98060 | - |
dc.description.abstract | Background/Aim: Although several epidemiological studies have indicated that statins may have antitumor properties, the effect of statins on patient survival after curative resection of gastric cancer is unknown. The aim of the present study was to determine whether statin use could improve long-term outcomes after radical gastrectomy. Patiens and Methods: We conducted a matched case–control study of 65 statin users and 176 non-users who underwent radical gastrectomy for stage II and III gastric cancer from January 2006 to December 2009. Results: No significant differences were found in recurrence-free survival (RFS) or overall survival (OS) between statin users and non-users. However, subgroup analysis showed that patients who used statins for more than six months had more favorable outcomes than non-users or those who used statins for less than six months [adjusted hazard ratio of death (non-users as reference); statin use <6 months: 2.405, 95% confidence interval (CI)=1.056-5.477 and statin use >6 months: 0.168, 95% CI=0.032-0.881, p=0.006]. Conclusion: Statin use did not improve RFS or OS after curative resection of stage II or III gastric cancer in the overall study population. However, statin use of more than six months was associated with increased survival. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 355~361 | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/mortality* | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Adenocarcinoma/therapy | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Signet Ring Cell/mortality* | - |
dc.subject.MESH | Carcinoma, Signet Ring Cell/pathology | - |
dc.subject.MESH | Carcinoma, Signet Ring Cell/therapy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Gastrectomy/mortality* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use* | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Stomach Neoplasms/mortality* | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | Stomach Neoplasms/therapy | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Long-term Statin Therapy Improves Oncological Outcome After Radical Gastrectomy for Stage II and III Gastric Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | DONG HYUK NAM | - |
dc.contributor.googleauthor | HYUK LEE | - |
dc.contributor.googleauthor | JUN CHUL PARK | - |
dc.contributor.googleauthor | SUNG KWAN SHIN | - |
dc.contributor.googleauthor | SANG KIL LEE | - |
dc.contributor.googleauthor | WOO JIN HYUNG | - |
dc.contributor.googleauthor | YONG CHAN LEE | - |
dc.contributor.googleauthor | MIN WOONG KANG | - |
dc.contributor.googleauthor | SUNG HOON NOH | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A01676 | - |
dc.contributor.localId | A02112 | - |
dc.contributor.localId | A02812 | - |
dc.contributor.localId | A02988 | - |
dc.contributor.localId | A03285 | - |
dc.contributor.localId | A04382 | - |
dc.contributor.localId | A00027 | - |
dc.contributor.localId | A01247 | - |
dc.relation.journalcode | J00188 | - |
dc.identifier.eissn | 1791-7530 | - |
dc.identifier.pmid | 24403487 | - |
dc.identifier.url | http://ar.iiarjournals.org/content/34/1/355.long | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | radical gastrectomy | - |
dc.subject.keyword | statin therapy | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Park, Jun Chul | - |
dc.contributor.alternativeName | Shin, Sung Kwan | - |
dc.contributor.alternativeName | Lee, Sang Kil | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.alternativeName | Lee, Hyuk | - |
dc.contributor.alternativeName | Hyung, Woo Jin | - |
dc.contributor.alternativeName | Kang, Min Woong | - |
dc.contributor.alternativeName | Nam, Dong Hyuk | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Park, Jun Chul | - |
dc.contributor.affiliatedAuthor | Shin, Sung Kwan | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | Lee, Hyuk | - |
dc.contributor.affiliatedAuthor | Hyung, Woo Jin | - |
dc.contributor.affiliatedAuthor | Kang, Min Woong | - |
dc.contributor.affiliatedAuthor | Nam, Dong Hyuk | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 355 | - |
dc.citation.endPage | 361 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, Vol.34(1) : 355-361, 2014 | - |
dc.identifier.rimsid | 54362 | - |
dc.type.rims | ART | - |
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