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백서 피하층에서 흡수성 차단막의 초기 조직 반응

Other Titles
 Initial tissue response of biodegradable membrane in rat subcutaneous model 
 임현창  ;  채경준  ;  최성호  ;  김종관  ;  조규성  ;  이용근  ;  김창성  ;  정의원 
 Journal of Korean Academy of Periodontology, Vol.37(4) : 839-848, 2007 
Journal Title
 Journal of Korean Academy of Periodontology (대한치주과학회지) 
Issue Date
Purpose: Various kinds of biodegradable membranes are currently used in dental clinics. And the frequency and the necessity of their usage are increasing due to their numerous advantages. Therefore it is important to understand the difference of various membranes and histological reaction against implanted membranes. Materials and Methods: Biodegradable membranes of $Biogide^®$, $Resolute^®$, and $Tutodent^®$ were cut into small pieces by $1.0{\times}0.5cm$. The membranes were implanted 1.5cm apart from each other under the epithelium on the skull of 18 Sprague Dawley rats. The animals were sacrificed at 3, 7, and 14 days after surgical procedure. The specimens were examined by histological analysis. Results: 1. Early period after implantation of the membranes showed connective tissues surrounding membranes and there were a few inflammatory cells present. 2. In $Biogide^®$ and $Tutodent^®$ specimens, inflammatory cells and surrounding tissues were shown to infiltrate from outside with slight density difference inside. In $Resolute^®$ specimens, membranes were fragmented. Inflammatory cells and connective tissues were also observed inside. 3. In $Resolute^®$ specimen, giant cells were present which implicates that foreign body reaction has occurred. 4. $Biogide^®$ had lower integrity than other membranes and is not enough to be used alone in defect area. However, $Resolute^®$ had superior firmness than others. $Tutodent^®$ had middle level of integrity. Conclusion: This experimental model enabled to observe early inflammatory reactions and morphological changes of materials and can be used to develop and evaluate the efficacy of biodegradable membranes. Duplication of standardized human oral environment will be required in future experiments.
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2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Lee, Yong Keun(이용근)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
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