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Accuracy of fluorodeoxyglucose-positron emission tomography for diagnosis of single bone metastasis: Comparison with bone scintigraphy

Authors
 Jin Hur  ;  Choon-Sik Yoon  ;  Jin-Suck Suh  ;  Mi Jin Yun  ;  Young Hoon Ryu 
Citation
 JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, Vol.31(5) : 812-819, 2007 
Journal Title
 JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 
ISSN
 0363-8715 
Issue Date
2007
MeSH
Adult ; Aged ; Analysis of Variance ; Bone Neoplasms/diagnostic imaging* ; Bone Neoplasms/secondary* ; Female ; Fluorodeoxyglucose F18* ; Humans ; Image Interpretation, Computer-Assisted ; Male ; Middle Aged ; Positron-Emission Tomography* ; ROC Curve ; Radiopharmaceuticals* ; Retrospective Studies ; Sensitivity and Specificity
Keywords
bone metastasis ; fluorodeoxyglucose- positron emission tomography (FDG-PET) ; bone scan
Abstract
PURPOSE: The aim of this study was to compare the accuracy of fluorodeoxyglucose-positron emission tomography (FDG-PET) with bone scan for diagnosis of single bone metastasis using a semiquantitative method. MATERIAL AND METHODS: Seventy-six patients with suspected single bone metastasis, who underwent both FDG-PET and a bone scan, were selected. The number and location of lesions detected upon both FDG-PET and bone scan were recorded, and the lesions were compared using the McNemar test. For semiquantitative analysis, a maximum (max) standard uptake value (SUV) of 2.5 was used as the positive cutoff value for metastasis. The difference in max SUV value among 3 groups (osteolytic, osteoblastic, and benign lesions) was assessed using the Student-Newman-Keuls method. Biopsy results, other imaging findings (multirow detector computed tomography, magnetic resonance imaging), and the patient's clinical course were used as references. RESULTS: There were 47 single bone metastases and 29 benign lesions. The sensitivity, specificity, and accuracy of bone scans for diagnosing bone metastases were 89%, 41%, and 71%, respectively, and those of FDG-PET were 85%, 52%, and 72%, respectively. These data were not significantly different (P > 0.05). Using a max SUV of 2.5 as the positive cutoff value for metastasis, the specificity and accuracy of FDG-PET, 83% for each, improved. When classifying bone metastasis as osteoblastic or osteolytic, the max SUV was significantly higher in osteolytic metastasis than in osteoblastic and benign lesions (P = 0.001). CONCLUSIONS: Fluorodeoxyglucose-positron emission tomography (FDG-PET) using the semiquantitative parameter SUV improves the diagnostic ability to differentiate between single bone metastases and benign lesions.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004728-200709000-00027&LSLINK=80&D=ovft
DOI
10.1097/rct.0b013e318031cc4d
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Yoon, Choon Sik(윤춘식) ORCID logo https://orcid.org/0000-0003-2010-6710
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96285
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