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Temporospatial tissue interactions regulating the regeneration of the enamel knot in the developing mouse tooth

Authors
 Sung-Won Cho  ;  Jae-Young Kim  ;  Han-Sung Jung  ;  Hitoshi Yamamoto  ;  Hyun-A Lee  ;  Eun-Jung Kim  ;  Jong-Min Lee  ;  Jinglei Cai 
Citation
 DIFFERENTIATION, Vol.75(2) : 158-165, 2007 
Journal Title
 DIFFERENTIATION 
ISSN
 0301-4681 
Issue Date
2007
MeSH
Animals ; Dental Enamel/physiology* ; Dental Enamel Proteins/metabolism ; Epithelium/physiology* ; Fibroblast Growth Factors/physiology ; Mesoderm/physiology* ; Mice ; Mice, Inbred ICR ; Regeneration/physiology* ; Tooth/embryology ; Tooth/physiology* ; Tooth Germ/physiology*
Abstract
The enamel knot (EK), which is a transient signaling center in the tooth germ, regulates both the differential growth of the dental epithelium and the tooth shape. In this study, the regeneration of the EK was evaluated. The EK regions were removed from the E14 and E16 dental epithelia, and the remaining epithelia were recombined with their original dental mesenchymes. All these tooth germs could develop into calcified teeth after being transplanted into the kidney capsule for 3 weeks. One primary EK was regenerated earlier, and two or three secondary EKs were regenerated later in culture. When simply recombined without removing the EK, the tooth germ, which had four secondary EKs and four cuspal areas of the dental papilla, generated one primary EK first and subsequent secondary EKs. These results indicate that the patterning of the EK in all tooth germs always starts from a primary EK independent of the direct epithelial or mesenchymal control. This suggests that neither the dental epithelium nor the dental mesenchyme can dictate the pattern or number of the EK formation, but the interaction between the dental epithelium and the dental mesenchyme is essential for the regeneration and patterning of the EKs.
Full Text
http://www.sciencedirect.com/science/article/pii/S0301468109601110
DOI
10.1111/j.1432-0436.2006.00122.x
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eun-Jung(김은정) ORCID logo https://orcid.org/0000-0002-9515-7590
Kim, Jae Young(김재영)
Lee, Jong Min(이종민) ORCID logo https://orcid.org/0000-0002-9466-7644
Lee, Hyun A(이현아)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95953
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