Effect of chitosan with absorbable collagen sponge carrier on bone regeneration in rat calvarial defect model

Abstract

The purpose of this study is to evaluate the effect of chitosan with absorbable collagen sponge (ACS) carrier on bone formation in the rat calvarial defect model. New bone area and defect closure of the chitosan/ACS group were significantly greater than those of the others at 8 weeks postsurgery (p < 0.01). Chitosan reconstituted with ACS has significant potential to induce the regeneration of bone in rat calvarial critical size defects.