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Effects of Scutellaria baicalensis on neurogenesis in the hippocampal dentate gyrus and on spatial memory of adult rats

Authors
 Sun-Hwa Lee  ;  Byung-soo Ahn  ;  Bong-soo Lim  ;  Seong-Kyu Kim  ;  Sam-Ki Kim  ;  Dae-Il Lee  ;  Sung-Rae Cho  ;  Deok-Gon Kim  ;  Jae-Bok Han  ;  Byung-Il Min 
Citation
 Neural Regeneration Research, Vol.6(27) : 2085-2093, 2011 
Journal Title
 Neural Regeneration Research 
ISSN
 1673-5374 
Issue Date
2011
Abstract
We investigated the effects of ethanol extracted Scutellaria baicalensis (EESB) on spatial memory function and neurogenesis in the hippocampal dentate gyrus. Adult Sprague-Dawley rats were orally administered 50, 100, or 200 mg/kg of EESB for 6 successive days. The radial-arm maze test showed that 200 mg/kg of EESB improved the spatial memory of adult rats. Confocal microscopy results showed that 100 mg/kg of EESB increased the number of bromodeoxyuridine (BrdU)- and neuron-specific nuclear protein-positive cells in the granular cell layer, and that 100 and 200 mg/kg of EESB increased the number of BrdU-/neuron-specific nuclear protein-positive cells in the sub-granular zone. 200 mg/kg of EESB increased the number of BrdU-/glial fibrillary acid protein-positive cells in the subgranular zone. These findings indicate that EESB can effectively promote neurogenesis in the hippocampal dentate gyrus and improve spatial memory function.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95309
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실)
Yonsei Authors
조성래(Cho, Sung Rae)
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