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Effects of Scutellaria baicalensis on neurogenesis in the hippocampal dentate gyrus and on spatial memory of adult rats

Authors
 Sun-Hwa Lee ; Byung-soo Ahn ; Byung-Il Min ; Jae-Bok Han ; Deok-Gon Kim ; Sung-Rae Cho ; Dae-Il Lee ; Sam-Ki Kim ; Seong-Kyu Kim ; Bong-soo Lim 
Citation
 Neural Regeneration Research, Vol.6(27) : 2085~2093, 2011 
Journal Title
 Neural Regeneration Research 
ISSN
 1673-5374 
Issue Date
2011
Abstract
We investigated the effects of ethanol extracted Scutellaria baicalensis (EESB) on spatial memory function and neurogenesis in the hippocampal dentate gyrus. Adult Sprague-Dawley rats were orally administered 50, 100, or 200 mg/kg of EESB for 6 successive days. The radial-arm maze test showed that 200 mg/kg of EESB improved the spatial memory of adult rats. Confocal microscopy results showed that 100 mg/kg of EESB increased the number of bromodeoxyuridine (BrdU)- and neuron-specific nuclear protein-positive cells in the granular cell layer, and that 100 and 200 mg/kg of EESB increased the number of BrdU-/neuron-specific nuclear protein-positive cells in the sub-granular zone. 200 mg/kg of EESB increased the number of BrdU-/glial fibrillary acid protein-positive cells in the subgranular zone. These findings indicate that EESB can effectively promote neurogenesis in the hippocampal dentate gyrus and improve spatial memory function.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/95309
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Rehabilitation Medicine
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