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Effects of Scutellaria baicalensis on neurogenesis in the hippocampal dentate gyrus and on spatial memory of adult rats

DC FieldValueLanguage
dc.contributor.author조성래-
dc.date.accessioned2014-12-20T17:49:03Z-
dc.date.available2014-12-20T17:49:03Z-
dc.date.issued2011-
dc.identifier.issn1673-5374-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95309-
dc.description.abstractWe investigated the effects of ethanol extracted Scutellaria baicalensis (EESB) on spatial memory function and neurogenesis in the hippocampal dentate gyrus. Adult Sprague-Dawley rats were orally administered 50, 100, or 200 mg/kg of EESB for 6 successive days. The radial-arm maze test showed that 200 mg/kg of EESB improved the spatial memory of adult rats. Confocal microscopy results showed that 100 mg/kg of EESB increased the number of bromodeoxyuridine (BrdU)- and neuron-specific nuclear protein-positive cells in the granular cell layer, and that 100 and 200 mg/kg of EESB increased the number of BrdU-/neuron-specific nuclear protein-positive cells in the sub-granular zone. 200 mg/kg of EESB increased the number of BrdU-/glial fibrillary acid protein-positive cells in the subgranular zone. These findings indicate that EESB can effectively promote neurogenesis in the hippocampal dentate gyrus and improve spatial memory function.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2085~2093-
dc.relation.isPartOfNEURAL REGENERATION RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of Scutellaria baicalensis on neurogenesis in the hippocampal dentate gyrus and on spatial memory of adult rats-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Rehabilitation Medicine (재활의학)-
dc.contributor.googleauthorSun-Hwa Lee-
dc.contributor.googleauthorByung-soo Ahn-
dc.contributor.googleauthorBong-soo Lim-
dc.contributor.googleauthorSeong-Kyu Kim-
dc.contributor.googleauthorSam-Ki Kim-
dc.contributor.googleauthorDae-Il Lee-
dc.contributor.googleauthorSung-Rae Cho-
dc.contributor.googleauthorDeok-Gon Kim-
dc.contributor.googleauthorJae-Bok Han-
dc.contributor.googleauthorByung-Il Min-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03831-
dc.relation.journalcodeJ02320-
dc.identifier.eissn1876-7958-
dc.contributor.alternativeNameCho, Sung Rae-
dc.contributor.affiliatedAuthorCho, Sung Rae-
dc.citation.volume6-
dc.citation.number27-
dc.citation.startPage2085-
dc.citation.endPage2093-
dc.identifier.bibliographicCitationNEURAL REGENERATION RESEARCH, Vol.6(27) : 2085-2093, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers

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