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Wound healing/regeneration using recombinant human growth/differentiation factor-5 in an injectable poly-lactide-co-glycolide-acid composite carrier and a one-wall intra-bony defect model in dogs

Authors
 Cheon-Ki Min  ;  Ulf M. E. Wikesjö  ;  Jung-Chul Park  ;  Gyung-Joon Chae  ;  Susanne D. Pippig  ;  Patrizia Bastone  ;  Chang-Sung Kim  ;  Chong-Kwan Kim 
Citation
 JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.38(3) : 261-268, 2011 
Journal Title
 JOURNAL OF CLINICAL PERIODONTOLOGY 
ISSN
 0303-6979 
Issue Date
2011
MeSH
Absorbable Implants ; Alveolar Bone Loss/surgery* ; Alveolar Process/drug effects ; Alveolar Process/pathology ; Animals ; Biocompatible Materials/chemistry* ; Cementogenesis/drug effects ; Connective Tissue/drug effects ; Connective Tissue/pathology ; Dental Cementum/drug effects ; Dental Cementum/pathology ; Dogs ; Dose-Response Relationship, Drug ; Drug Carriers ; Epithelium/drug effects ; Epithelium/pathology ; Growth Differentiation Factor 5/administration & dosage ; Growth Differentiation Factor 5/therapeutic use* ; Guided Tissue Regeneration, Periodontal/methods ; Humans ; Lactic Acid/chemistry* ; Male ; Osteogenesis/drug effects ; Polyglycolic Acid/chemistry* ; Random Allocation ; Recombinant Proteins ; Regeneration/drug effects ; Time Factors ; Wound Healing/drug effects
Keywords
dog ; periodontal regeneration ; PLGA ; rhGDF-5 ; tissue engineering
Abstract
OBJECTIVE: The purpose of this study was to evaluate the effect of recombinant human growth/differentiation factor-5 (rhGDF-5) on periodontal wound healing/regeneration using an injectable poly-lactide-co-glycolide-acid (PLGA) composite carrier and an established defect model. METHODS: Bilateral 4 × 5 mm (width × depth) one-wall, critical-size, intra-bony periodontal defects were surgically created at the second and the fourth mandibular pre-molar teeth in 15 Beagle dogs. The animals were randomized to receive (using a split-mouth design; defect sites in the same jaw quadrant getting the same treatment) rhGDF-5 high dose (188 μg/defect) versus sham-surgery control (five animals), rhGDF-5 mid dose (37 μg/defect) versus carrier control (five animals), and rhGDF-5 low dose (1.8 μg/defect) versus treatment reported elsewhere (five animals). The animals were euthanized for histometric analysis following an 8-week healing interval. RESULTS: Clinical healing was uneventful. The rhGDF-5/PLGA construct was easy to assemble and apply. The rhGDF-5 high dose supported significantly increased bone formation compared with the low-dose, sham-surgery, and carrier controls (p<0.05) and induced significantly increased cementum formation compared with the controls (p<0.05). Root resorption/ankylosis or other aberrant healing events were not observed. CONCLUSION: rhGDF-5 appears to effectively support periodontal wound healing/regeneration in a dose-dependent order; the PLGA composite appears to be an effective ease-of-use candidate for carrier technology.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2010.01691.x/abstract
DOI
10.1111/j.1600-051X.2010.01691.x
Appears in Collections:
5. Research Institutes (연구소) > Research Center for Orofacial Hard Tissue Regeneration (구강악안면경조직재생연구센터) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Park, Jung Chul(박정철)
Chae, Gyung Joon(채경준)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95298
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