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Wound healing/regeneration using recombinant human growth/differentiation factor-5 in an injectable poly-lactide-co-glycolide-acid composite carrier and a one-wall intra-bony defect model in dogs

DC FieldValueLanguage
dc.contributor.author김종관-
dc.contributor.author김창성-
dc.contributor.author박정철-
dc.contributor.author채경준-
dc.date.accessioned2014-12-20T17:48:43Z-
dc.date.available2014-12-20T17:48:43Z-
dc.date.issued2011-
dc.identifier.issn0303-6979-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95298-
dc.description.abstractOBJECTIVE: The purpose of this study was to evaluate the effect of recombinant human growth/differentiation factor-5 (rhGDF-5) on periodontal wound healing/regeneration using an injectable poly-lactide-co-glycolide-acid (PLGA) composite carrier and an established defect model. METHODS: Bilateral 4 × 5 mm (width × depth) one-wall, critical-size, intra-bony periodontal defects were surgically created at the second and the fourth mandibular pre-molar teeth in 15 Beagle dogs. The animals were randomized to receive (using a split-mouth design; defect sites in the same jaw quadrant getting the same treatment) rhGDF-5 high dose (188 μg/defect) versus sham-surgery control (five animals), rhGDF-5 mid dose (37 μg/defect) versus carrier control (five animals), and rhGDF-5 low dose (1.8 μg/defect) versus treatment reported elsewhere (five animals). The animals were euthanized for histometric analysis following an 8-week healing interval. RESULTS: Clinical healing was uneventful. The rhGDF-5/PLGA construct was easy to assemble and apply. The rhGDF-5 high dose supported significantly increased bone formation compared with the low-dose, sham-surgery, and carrier controls (p<0.05) and induced significantly increased cementum formation compared with the controls (p<0.05). Root resorption/ankylosis or other aberrant healing events were not observed. CONCLUSION: rhGDF-5 appears to effectively support periodontal wound healing/regeneration in a dose-dependent order; the PLGA composite appears to be an effective ease-of-use candidate for carrier technology.-
dc.description.statementOfResponsibilityopen-
dc.format.extent261~268-
dc.relation.isPartOfJOURNAL OF CLINICAL PERIODONTOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAbsorbable Implants-
dc.subject.MESHAlveolar Bone Loss/surgery*-
dc.subject.MESHAlveolar Process/drug effects-
dc.subject.MESHAlveolar Process/pathology-
dc.subject.MESHAnimals-
dc.subject.MESHBiocompatible Materials/chemistry*-
dc.subject.MESHCementogenesis/drug effects-
dc.subject.MESHConnective Tissue/drug effects-
dc.subject.MESHConnective Tissue/pathology-
dc.subject.MESHDental Cementum/drug effects-
dc.subject.MESHDental Cementum/pathology-
dc.subject.MESHDogs-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHDrug Carriers-
dc.subject.MESHEpithelium/drug effects-
dc.subject.MESHEpithelium/pathology-
dc.subject.MESHGrowth Differentiation Factor 5/administration & dosage-
dc.subject.MESHGrowth Differentiation Factor 5/therapeutic use*-
dc.subject.MESHGuided Tissue Regeneration, Periodontal/methods-
dc.subject.MESHHumans-
dc.subject.MESHLactic Acid/chemistry*-
dc.subject.MESHMale-
dc.subject.MESHOsteogenesis/drug effects-
dc.subject.MESHPolyglycolic Acid/chemistry*-
dc.subject.MESHRandom Allocation-
dc.subject.MESHRecombinant Proteins-
dc.subject.MESHRegeneration/drug effects-
dc.subject.MESHTime Factors-
dc.subject.MESHWound Healing/drug effects-
dc.titleWound healing/regeneration using recombinant human growth/differentiation factor-5 in an injectable poly-lactide-co-glycolide-acid composite carrier and a one-wall intra-bony defect model in dogs-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentDept. of Periodontology, Research Center for Orofacial Hard Tissue Regeneration (구강악안면경조직재생연구센터)-
dc.contributor.googleauthorCheon-Ki Min-
dc.contributor.googleauthorUlf M. E. Wikesjö-
dc.contributor.googleauthorJung-Chul Park-
dc.contributor.googleauthorGyung-Joon Chae-
dc.contributor.googleauthorSusanne D. Pippig-
dc.contributor.googleauthorPatrizia Bastone-
dc.contributor.googleauthorChang-Sung Kim-
dc.contributor.googleauthorChong-Kwan Kim-
dc.identifier.doi10.1111/j.1600-051X.2010.01691.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01041-
dc.contributor.localIdA01653-
dc.contributor.localIdA04011-
dc.contributor.localIdA00914-
dc.relation.journalcodeJ01337-
dc.identifier.eissn1600-051X-
dc.identifier.pmid21219393-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2010.01691.x/abstract-
dc.subject.keyworddog-
dc.subject.keywordperiodontal regeneration-
dc.subject.keywordPLGA-
dc.subject.keywordrhGDF-5-
dc.subject.keywordtissue engineering-
dc.contributor.alternativeNameKim, Chong Kwan-
dc.contributor.alternativeNameKim, Chang Sung-
dc.contributor.alternativeNamePark, Jung Chul-
dc.contributor.alternativeNameChae, Gyung Joon-
dc.contributor.affiliatedAuthorKim, Chang Sung-
dc.contributor.affiliatedAuthorPark, Jung Chul-
dc.contributor.affiliatedAuthorChae, Gyung Joon-
dc.contributor.affiliatedAuthorKim, Chong Kwan-
dc.rights.accessRightsnot free-
dc.citation.volume38-
dc.citation.number3-
dc.citation.startPage261-
dc.citation.endPage268-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL PERIODONTOLOGY, Vol.38(3) : 261-268, 2011-
Appears in Collections:
5. Research Institutes (연구소) > Research Center for Orofacial Hard Tissue Regeneration (구강악안면경조직재생연구센터) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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