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Foam sclerotherapy using polidocanol (aethoxysklerol) for preoperative portal vein embolization in 16 patients.

Authors
 Sang-Hoon Chung  ;  Myung-su Lee  ;  Kyung Sik Kim  ;  Soon II Kim  ;  Jong Youn Won  ;  Do Yun Lee  ;  Kwang-Hun Lee 
Citation
 CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, Vol.34(6) : 1236-1243, 2011 
Journal Title
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
ISSN
 0174-1551 
Issue Date
2011
MeSH
Aged ; Angiography ; Contrast Media/therapeutic use ; Embolization, Therapeutic/methods* ; Female ; Humans ; Imaging, Three-Dimensional ; Liver Function Tests ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/therapy* ; Male ; Middle Aged ; Polyethylene Glycols/administration & dosage* ; Portal Vein* ; Radiographic Image Interpretation, Computer-Assisted ; Sclerosing Solutions/administration & dosage* ; Sclerotherapy/methods* ; Tomography, X-Ray Computed ; Treatment Outcome
Abstract
PURPOSE: To evaluate the clinical safety and effectiveness of foam sclerotherapy using polidocanol for preoperative portal vein embolization (PVE) before hemihepatectomy of the liver.

MATERIALS AND METHODS: From March 2006 to October 2008, foam sclerotherapy using polidocanol was performed in 16 patients (male-to-female ratio of 12:4, age range 48-75 years [mean 62]) for PVE. Patients were diagnosed with Klatskin tumor (n = 13), gallbladder (GB) cancer (n = 2), or hepatocellular carcinoma (HCC) (n = 1). The foam was composed of a 1:2:1 ratio of 3% polidocanol (Aethoxysklerol; Kreussler Pharma, Wiesbaden, Germany), room air, and contrast media (Xenetix 350; Guerbet, Aulnay-Sous-Bois, France). The total amount of polidocanol used (2 to 8 mL [mean 4.6]) varied according to the volume of the target portal vein. We calculated the volume of future liver remnant (FLR) before and after PVE and evaluated complications associated with the use of polidocanol foam sclerotherapy for PVE.

RESULTS: Technical success was achieved in all patients. All patients were comfortable throughout the procedure and did not experience pain during sclerotherapy. No periprocedural morbidity or mortality occurred. Patients underwent a liver dynamic computed tomography (CT) scan 2-4 weeks after PVE. FLR increased significantly after PVE using polidocanol foam from 19.3% (range 16-35%) before PVE to 27.8% (range 23-42%) after PVE (p = 0.001). All patients were operable for hemihepatectomy of the liver and achieved effective resection.

CONCLUSION: Foam sclerotherapy using polidocanol is clinically safe and effective for preoperative PVE.
Full Text
http://link.springer.com/article/10.1007%2Fs00270-010-0079-5
DOI
10.1007/s00270-010-0079-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Soon Il(김순일) ORCID logo https://orcid.org/0000-0002-0783-7538
Won, Jong Yun(원종윤) ORCID logo https://orcid.org/0000-0002-8237-5628
Lee, Kwang Hun(이광훈)
Lee, Do Yun(이도연)
Lee, Myung Su(이명수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95244
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