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노화관련 질환에서 mTOR의 억제제의 임상적 적용과 가능성

Other Titles
 mTOR Inhibitor as a Potential Drug of Age-related Disease 
Authors
 신현영  ;  추상희  ;  이지원  ;  이향규 
Citation
 Korean Journal of Clinical Geriatrics (임상노인의학회지), Vol.12(4) : 149-159, 2011 
Journal Title
 Korean Journal of Clinical Geriatrics  (임상노인의학회지) 
ISSN
 1229-6538 
Issue Date
2011
Abstract
mTOR (mammalian target of rapamycin) is a serine/threonine kinase belonging to the PI3K (phosphoinositide 3-kinase)-related family kinase. mTOR is known to regulate cell growth, proliferation, autophagy and protein synthesis in response to growth factor, nutrient, stress. mTOR inhibitor has been broadly used as an immunosuppressant for kidney transplant patients. Clinical results of the data have showed mTOR inhibitor as an anticancer agent to several kinds of cancers and many clinical trials are still undergoing. Recently, mTOR signaling pathway has been studied with, not only metabolic disease, neurodegenerative disease, cardiovascular disease, which are related to the ageing process, but also the possibility of direct prolongation of human life. However, the studies of mTOR pathway with age-related disease are still in the early stage, we need more studies about increasing infectivity after immunosuppression and other adverse events of mTOR inhibitor. In this article, we will review age-related disease with mTOR pathway and discuss mTOR inhibitor as a potential agent for extending healthy life in the future.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95071
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)
1. Journal Papers (연구논문) > 3. College of Nursing (간호대학) > Dept. of Nursing (간호학과)
Yonsei Authors
이지원(Lee, Ji Won) ; 이향규(Lee, Hyang Kyu) ; 추상희(Choo, Sang Hee)
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