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The ratio of intra-tumoral regulatory T cells (Foxp3+)/helper T cells (CD4+) is a prognostic factor and associated with recurrence pattern in gastric cardia cancer.

Authors
 Hyoung-Il Kim  ;  Haeryoung Kim  ;  Hyoung Won Cho  ;  Sang Yong Kim  ;  Ki Jun Song  ;  Woo Jin Hyung  ;  Chung-Gyu Park  ;  Choong-Bai Kim 
Citation
 JOURNAL OF SURGICAL ONCOLOGY, Vol.104(7) : 728-733, 2011 
Journal Title
JOURNAL OF SURGICAL ONCOLOGY
ISSN
 0022-4790 
Issue Date
2011
MeSH
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism* ; CD4-Positive T-Lymphocytes/metabolism* ; Cardia* ; Female ; Forkhead Transcription Factors/metabolism* ; Humans ; Immunohistochemistry ; Lymphocyte Count ; Lymphocytes, Tumor-Infiltrating/metabolism* ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local/pathology* ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Stomach Neoplasms/pathology* ; Survival Analysis ; T-Lymphocytes, Regulatory/metabolism*
Keywords
regulatory T lymphocytes ; tumor-infiltrating lymphocytes ; stomach neoplasms ; surviva
Abstract
BACKGROUND: TILs have been reported to be a prognostic factor in human cancers. We assessed the prognostic significance of tumor-infiltrating regulatory T cells in gastric cardia cancer.

METHODS: We retrospectively reviewed the database of Severance Hospital for patients who underwent curative resection of gastric cardia cancer from Jan 2000 to Dec 2006 and identified 180 patients. Immunohistochemistry for TIL subsets was performed against CD3, CD4, CD8, Foxp3, and granzyme B in the resected tumor specimens. The absolute numbers and relative ratios of positively stained lymphocytes for each subset were evaluated.

RESULTS: A high Foxp3/CD4 ratio was identified as an unfavorable prognostic factor for overall survival (OS) using univariate and multivariate analysis of all immunologic variables. Patients group with high Foxp3/CD4 ratio was associated with loco-regional recurrence (P = 0.033). In multivariate analysis for clinical and immunologic variables, the nodal status (hazards ratio--HR: 3.863, confidence interval--CI: 1.664-8.966, P = 0.002), depth of invasion (HR: 3.607, CI: 1.443-9.019, P = 0.006), and Foxp3/CD4 ratio (HR: 1.812, CI: 1.022-3.212, P = 0.042) were identified as independent prognostic factors for OS.

CONCLUSIONS: A higher regulatory T cells/helper T cells ratio is associated with an unfavorable prognosis and loco-regional recurrence pattern in gastric cardia cancer.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.22038/abstract
DOI
10.1002/jso.22038
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Sang Yong(김상용)
Kim, Choong Bai(김충배)
Kim, Hyoung Il(김형일) ORCID logo https://orcid.org/0000-0002-6134-4523
Song, Ki Jun(송기준) ORCID logo https://orcid.org/0000-0003-2505-4112
Cho, Hyoung Won(조형원)
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94888
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