Cited 65 times in

The association between cerebral atherosclerosis and arterial stiffness in acute ischemic stroke

Authors
 Jinkwon Kim  ;  Myoung-Jin Cha  ;  Dong Hyun Lee  ;  Hye Sun Lee  ;  Chung Mo Nam  ;  Hyo Suk Nam  ;  Young Dae Kim  ;  Ji Hoe Heo 
Citation
 ATHEROSCLEROSIS, Vol.219(2) : 887-891, 2011 
Journal Title
ATHEROSCLEROSIS
ISSN
 0021-9150 
Issue Date
2011
MeSH
Aged ; Angiography, Digital Subtraction ; Ankle Brachial Index ; Brain Ischemia/diagnosis ; Brain Ischemia/epidemiology ; Brain Ischemia/physiopathology* ; Cerebral Angiography/methods ; Cerebral Arteries/diagnostic imaging ; Cerebral Arteries/physiopathology* ; Cross-Sectional Studies ; Elasticity ; Female ; Humans ; Intracranial Arteriosclerosis/diagnosis ; Intracranial Arteriosclerosis/epidemiology ; Intracranial Arteriosclerosis/physiopathology* ; Linear Models ; Magnetic Resonance Angiography ; Male ; Middle Aged ; Multivariate Analysis ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/epidemiology ; Peripheral Arterial Disease/physiopathology* ; Pulsatile Flow* ; Registries ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/physiopathology* ; Tomography, X-Ray Computed
Keywords
Arterial stiffness ; Atherosclerosis ; Pulse wave velocity ; Ischemic stroke
Abstract
OBJECTIVE: Arterial stiffness is associated with cardiovascular risk factors and atherosclerosis. Measurement of pulse wave velocity (PWV) is one of the most representative and noninvasive techniques for assessing arterial stiffness. We investigated the association of cerebral atherosclerosis with brachial-ankle PWV (baPWV) in acute ischemic stroke patients. If present, we sought to determine whether the relationship differed between atherosclerosis in the intracranial artery and atherosclerosis in the extracranial artery.

METHODS: We included 801 patients with acute ischemic stroke who had undergone angiographic study and baPWV measurement between January 2007 and May 2010. Patients with cerebral artery atherosclerosis were categorized into those with intracranial atherosclerosis, those with extracranial atherosclerosis and those with both intracranial and extracranial atherosclerosis. We determined factors that were associated with baPWV.

RESULTS: Univariate and multivariate analyses showed that high baPWV was significantly associated with older age, lower body mass index, higher brachial systolic pressure, and diabetes mellitus. Increased baPWV was associated with the presence of atherosclerosis (≥ 50% stenosis) in the intracranial cerebral artery as well as in both the intracranial and extracranial arteries, but not with atherosclerosis in the extracranial cerebral artery. The burden of intracranial cerebral atherosclerosis, which was assessed based on the number of arteries with atherosclerosis, was also closely associated with baPWV.

CONCLUSION: Arterial stiffness was associated with the presence and burden of intracranial cerebral atherosclerosis in stroke patients, but was not associated with the extracranial cerebral atherosclerosis. These findings suggest a potential pathophysiological association between increased arterial stiffness and intracranial cerebral atherosclerosis.
Full Text
http://www.sciencedirect.com/science/article/pii/S0021915011009178
DOI
10.1016/j.atherosclerosis.2011.09.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Kim, Jinkwon(김진권) ORCID logo https://orcid.org/0000-0003-0156-9736
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Cha, Myoung Jin(차명진)
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94575
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links