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Development of a pH-sensitive polymer using poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) for acidic pH targeting systems

Authors
 Ji Hoon Kim ; Young Taik Oh ; Kyung Taek Oh ; Byung Tae Park ; Jeong Min Yun ; Kyung Soo Lee 
Citation
 Macromolecular Research, Vol.19(5) : 453~460, 2011 
Journal Title
 Macromolecular Research 
ISSN
 1598-5032 
Issue Date
2011
Abstract
pH sensitive polymer systems can be utilized as smart nanocarriers to deliver hydrophobic drugs specifically to solid tumors or to acidosis-affected rheumatic joints. In this study, a poly(L-aspartic acid-graftimidazole)-block-poly(ethylene glycol) (P(Asp-g-Im)-PEG) block copolymer was synthesized as a pH sensitive nanocarrier targeting acidic pH environments. The polypeptide P(Asp), which was used as a backbone for the hydrophobic block, was synthesized by ring opening polymerization with N-carboxylanhydride (NCA) of β-benzyl-aspartic acid. PEG was included as the hydrophilic block and the polymer was functionalized with imidazole groups to confer pH sensitivity. The prepared P(Asp-g-Im)-PEG is zwitterionic with a pI 6.5; 60% of the available carboxyl groups of P(Asp)-PEG were substituted by imidazole groups. Furthermore, the potentiometric titration curve of P(Asp-g-Im)-PEG demonstrated a broad buffer zone. The micelles prepared from P(Asp-g-Im)-PEG showed pH dependent critical micelle concentrations (CMC), particle sizes, zeta potentials, and morphologies.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94241
DOI
10.1007/s13233-011-0502-z
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
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Link
 http://link.springer.com/article/10.1007%2Fs13233-011-0502-z#
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