Cited 31 times in
Development of a pH-sensitive polymer using poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) for acidic pH targeting systems
DC Field | Value | Language |
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dc.contributor.author | 오영택 | - |
dc.date.accessioned | 2014-12-20T17:15:02Z | - |
dc.date.available | 2014-12-20T17:15:02Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94241 | - |
dc.description.abstract | pH sensitive polymer systems can be utilized as smart nanocarriers to deliver hydrophobic drugs specifically to solid tumors or to acidosis-affected rheumatic joints. In this study, a poly(L-aspartic acid-graftimidazole)-block-poly(ethylene glycol) (P(Asp-g-Im)-PEG) block copolymer was synthesized as a pH sensitive nanocarrier targeting acidic pH environments. The polypeptide P(Asp), which was used as a backbone for the hydrophobic block, was synthesized by ring opening polymerization with N-carboxylanhydride (NCA) of β-benzyl-aspartic acid. PEG was included as the hydrophilic block and the polymer was functionalized with imidazole groups to confer pH sensitivity. The prepared P(Asp-g-Im)-PEG is zwitterionic with a pI 6.5; 60% of the available carboxyl groups of P(Asp)-PEG were substituted by imidazole groups. Furthermore, the potentiometric titration curve of P(Asp-g-Im)-PEG demonstrated a broad buffer zone. The micelles prepared from P(Asp-g-Im)-PEG showed pH dependent critical micelle concentrations (CMC), particle sizes, zeta potentials, and morphologies. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 453~460 | - |
dc.relation.isPartOf | MACROMOLECULAR RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Development of a pH-sensitive polymer using poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) for acidic pH targeting systems | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Ji Hoon Kim | - |
dc.contributor.googleauthor | Young Taik Oh | - |
dc.contributor.googleauthor | Kyung Soo Lee | - |
dc.contributor.googleauthor | Jeong Min Yun | - |
dc.contributor.googleauthor | Byung Tae Park | - |
dc.contributor.googleauthor | Kyung Taek Oh | - |
dc.identifier.doi | 10.1007/s13233-011-0502-z | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02390 | - |
dc.relation.journalcode | J02177 | - |
dc.identifier.eissn | 2092-7673 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs13233-011-0502-z# | - |
dc.subject.keyword | pH sensitive | - |
dc.subject.keyword | micelle destabilization | - |
dc.subject.keyword | nanocarrier | - |
dc.subject.keyword | polyelectrolytes | - |
dc.subject.keyword | poly(aspartic acid-graft-imidazole) | - |
dc.contributor.alternativeName | Oh, Young Taik | - |
dc.contributor.affiliatedAuthor | Oh, Young Taik | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 19 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 453 | - |
dc.citation.endPage | 460 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR RESEARCH, Vol.19(5) : 453-460, 2011 | - |
dc.identifier.rimsid | 27486 | - |
dc.type.rims | ART | - |
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