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NF-κB and CREB are involved in IL-8 production of human neutrophils induced by Trichomonas vaginalis-derived secretory products.

Authors
 Young Hee Nam  ;  Deulle Min  ;  Myeong Heon Shin  ;  Young Ah Lee  ;  Kyeong Ah Kim  ;  Soon-Jung Park 
Citation
 Korean Journal of Parasitology, Vol.49(3) : 291-294, 2011 
Journal Title
 Korean Journal of Parasitology 
ISSN
 0023-4001 
Issue Date
2011
Abstract
Trichomonas vaginalis is a flagellated lumen-dwelling extracellular protozoan parasite that causes human trichomoniasis via sexual intercourse. Human neutrophils play a crucial role in acute tissue inflammatory responses in T. vaginalis infection. In this study, we investigated the signaling mechanism of neutrophil responses when stimulated with T. vaginalis-derived secretory products (TvSP), which were collected from 1×10(7) live trichomonads. Incubation of human neutrophils isolated from peripheral blood with TvSP induced up-regulation of IL-8 protein secretion. In addition, stimulation with TvSP induced phosphorylation of NF-κB and CREB in neutrophils. Moreover, TvSP-induced IL-8 production was also significantly inhibited by pretreatment of neutrophils with iκB inhibitor or CREB inhibitor. These results suggest that transcription factors NF-κB and CREB are involved in IL-8 production in human neutrophils induced by stimulation with T. vaginalis infection.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94126
DOI
10.3347/kjp.2011.49.3.291
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
김경아(Kim, Kyung Ah) ; 남영희(Nam, Young Hee) ; 민아림(Min, A Rim) ; 박순정(Park, Soon Jung) ; 신명헌(Shin, Myeong Heon) ; 이영아(Lee, Young Ah)
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