Cited 9 times in
NF-κB and CREB are involved in IL-8 production of human neutrophils induced by Trichomonas vaginalis-derived secretory products.
DC Field | Value | Language |
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dc.contributor.author | 박순정 | - |
dc.contributor.author | 신명헌 | - |
dc.contributor.author | 이영아 | - |
dc.contributor.author | 김경아 | - |
dc.contributor.author | 남영희 | - |
dc.contributor.author | 민아림 | - |
dc.date.accessioned | 2014-12-20T17:11:23Z | - |
dc.date.available | 2014-12-20T17:11:23Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94126 | - |
dc.description.abstract | Trichomonas vaginalis is a flagellated lumen-dwelling extracellular protozoan parasite that causes human trichomoniasis via sexual intercourse. Human neutrophils play a crucial role in acute tissue inflammatory responses in T. vaginalis infection. In this study, we investigated the signaling mechanism of neutrophil responses when stimulated with T. vaginalis-derived secretory products (TvSP), which were collected from 1×10(7) live trichomonads. Incubation of human neutrophils isolated from peripheral blood with TvSP induced up-regulation of IL-8 protein secretion. In addition, stimulation with TvSP induced phosphorylation of NF-κB and CREB in neutrophils. Moreover, TvSP-induced IL-8 production was also significantly inhibited by pretreatment of neutrophils with iκB inhibitor or CREB inhibitor. These results suggest that transcription factors NF-κB and CREB are involved in IL-8 production in human neutrophils induced by stimulation with T. vaginalis infection. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 291~294 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cyclic AMP Response Element-Binding Protein/metabolism* | - |
dc.subject.MESH | HumanExperimentation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-8/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | NF-kappa B/metabolism* | - |
dc.subject.MESH | Neutrophils/immunology* | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Trichomonasvaginalis/immunology* | - |
dc.title | NF-κB and CREB are involved in IL-8 production of human neutrophils induced by Trichomonas vaginalis-derived secretory products. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | Young Hee Nam | - |
dc.contributor.googleauthor | Deulle Min | - |
dc.contributor.googleauthor | Soon-Jung Park | - |
dc.contributor.googleauthor | Kyeong Ah Kim | - |
dc.contributor.googleauthor | Young Ah Lee | - |
dc.contributor.googleauthor | Myeong Heon Shin | - |
dc.identifier.doi | 10.3347/kjp.2011.49.3.291 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01545 | - |
dc.contributor.localId | A02099 | - |
dc.contributor.localId | A02959 | - |
dc.contributor.localId | A01258 | - |
dc.contributor.localId | A01405 | - |
dc.contributor.localId | A00300 | - |
dc.relation.journalcode | J01957 | - |
dc.identifier.eissn | 1738-0006 | - |
dc.identifier.pmid | 22072831 | - |
dc.subject.keyword | Trichomonas vaginalis | - |
dc.subject.keyword | human neutrophil | - |
dc.subject.keyword | IL-8 | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | CREB | - |
dc.contributor.alternativeName | Park, Soon Jung | - |
dc.contributor.alternativeName | Shin, Myeong Heon | - |
dc.contributor.alternativeName | Lee, Young Ah | - |
dc.contributor.alternativeName | Kim, Kyung Ah | - |
dc.contributor.alternativeName | Nam, Young Hee | - |
dc.contributor.alternativeName | Min, A Rim | - |
dc.contributor.affiliatedAuthor | Park, Soon Jung | - |
dc.contributor.affiliatedAuthor | Shin, Myeong Heon | - |
dc.contributor.affiliatedAuthor | Lee, Young Ah | - |
dc.contributor.affiliatedAuthor | Nam, Young Hee | - |
dc.contributor.affiliatedAuthor | Min, A Rim | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Ah | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 49 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 291 | - |
dc.citation.endPage | 294 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PARASITOLOGY, Vol.49(3) : 291-294, 2011 | - |
dc.identifier.rimsid | 27256 | - |
dc.type.rims | ART | - |
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