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The T2-shortening effect of gadolinium and the optimal conditions for maximizing the CNR for evaluating the biliary system: a phantom study.

 Mi-Jung Lee  ;  Myung-Joon Kim  ;  Choon-Sik Yoon  ;  Si Young Song  ;  Kyungsoo Park  ;  Woo Sun Kim 
 KOREAN JOURNAL OF RADIOLOGY, Vol.12(3) : 358-364, 2011 
Journal Title
Issue Date
Analysis of Variance ; Biliary Atresia/diagnosis ; Cholangiopancreatography, Magnetic Resonance/methods* ; Cholestasis/diagnosis ; Contrast Media/administration & dosage* ; Diagnosis, Differential ; Gadolinium DTPA/administration & dosage* ; Humans ; Image Processing, Computer-Assisted ; Linear Models ; Phantoms, Imaging*
Magnetic resonance imaging (MRI) ; Gadolinium ; Biliary system ; Phantom
OBJECTIVE: Clear depiction of the common bile duct is important when evaluating neonatal cholestasis in order to differentiate biliary atresia from other diseases. During MR cholangiopancreatography, the T2-shortening effect of gadolinium can increase the contrast-to-noise ratio (CNR) of the bile duct and enhance its depiction. The purpose of this study was to confirm, by performing a phantom study, the T2-shortening effect of gadolinium, to evaluate the effect of different gadolinium chelates with different gadolinium concentrations and different magnetic field strengths for investigating the optimal combination of these conditions, and for identifying the maximum CNR for the evaluation of the biliary system.

MATERIALS AND METHODS: MR imaging using a T2-weighted single-shot fast spin echo sequence and T2 relaxometry was performed with a sponge phantom in a syringe tube. Two kinds of contrast agents (Gd-DTPA and Gd-EOB-DTPA) with different gadolinium concentrations were evaluated with 1.5T and 3T scanners. The signal intensities, the CNRs and the T2 relaxation time were analyzed.

RESULTS: The signal intensities significantly decreased as the gadolinium concentrations increased (p < 0.001) with both contrast agents. These signal intensities were higher on a 3T (p < 0.001) scanner. The CNRs were higher on a 1.5T (p < 0.001) scanner and they showed no significant change with different gadolinium concentrations. The T2 relaxation time also showed a negative correlation with the gadolinium concentrations (p < 0.001) and the CNRs showed decrease more with Gd-EOB-DTPA (versus Gd-DTPA; p < 0.001) on a 3T scanner (versus 1.5T; p < 0.001).

CONCLUSION: A T2-shortening effect of gadolinium exhibits a negative correlation with the gadolinium concentration for both the signal intensities and the T2 relaxation time. A higher CNR can be obtained with Gd-DTPA on a 1.5T MRI scanner
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myung Joon(김명준) ORCID logo https://orcid.org/0000-0002-4608-0275
Park, Kyungsoo(박경수) ORCID logo https://orcid.org/0000-0002-6972-1143
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Yoon, Choon Sik(윤춘식) ORCID logo https://orcid.org/0000-0003-2010-6710
Lee, Mi-Jung(이미정) ORCID logo https://orcid.org/0000-0003-3244-9171
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