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내전형 연축성 발성장애 환자의 보툴리눔 독소-A 주입술 전후의 음성특성 비교

Other Titles
 Voice Characteristics of Adductor Spasmodic Dysphonia before and after Botulinum Toxin-A Injection 
 Boram Yun  ;  Hyang Hee Kim  ;  Yaelin Choi  ;  Hong-Shik Choi 
 Korean Journal of Otorhinolaryngology-Head and Neck Surgery, Vol.54(02) : 148-153, 2011 
Journal Title
 Korean Journal of Otorhinolaryngology-Head and Neck Surgery 
Issue Date
Spasmodic dysphonia ; Botulinum toxin ; Voice assessment
Background and ObjectivesZZBotulinum toxin type A (BTX-A) injection is well known for its effectiveness in the treatment of “Spasmodic dysphonia”. However, studies on the efficacy of BTX-A injection have not been attempted in Korea. Therefore, this study was carried out to investigate the effects of BTX-A. Subjects and MethodZZThe study examined 12 female patients with ‘adductor spasmodic dysphonia’. Objective assesments included aerodynamic analysis and electoroglottography (EGG) of each patient before and after BTX-A. Subjective assessments included using the Korean-version of Voice Handicap Index-30 (KVHI-30) and a patient self-rating scale. ResultsZZAerodynamic analysis revealed that only maximum phonation time (MPT) was significantly shortened after the injection of BTX-A (p<0.05). In the EGG, the mean frequency distribution was significantly increased, while the mean amplitude and the mean closed quotient distribution were significantly decreased (p<0.05). The KVHI-30 and patient selfrating scale scores were significantly decreased (p<0.01) as well, demonstrating the effects of BTX-A on the quality of life. ConclusionZZOur results show the effects of BTX-A objectively by comparing voice characteristics, which were measured through EGG before and after BTX-A injection, as well as by determining aerodynamic characteristics. The subjective self-assessment on the quality of life is significant as it may serve as a clinically relevant measure. This study may be helpful in elucidating treatment efficacy of BTX-A in many ways.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyang Hee(김향희) ORCID logo https://orcid.org/0000-0003-4949-2512
Choi, Hong Shik(최홍식)
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