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A prognostic model to predict clinical outcome in gastric cancer patients with bone metastasis

 Park H.S.  ;  Rha S.Y.  ;  Jeung H.-C.  ;  Noh S.H.  ;  Chung H.C.  ;  Park J.S.  ;  Hyung W.J.  ;  Kim H.S. 
 Oncology, Vol.80(1-2) : 142-150, 2011 
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BACKGROUND: The clinicopathological manifestations and treatment outcomes of bone metastasis of gastric cancer are largely unknown. We delineated a prognostic model to identify different risk groups on the basis of clinical parameters. METHODS: Patients who had bone metastasis at the time of diagnosis of gastric cancer (synchronous metastasis) or who developed bone metastasis during follow-up (metachronous metastasis) were retrospectively reviewed from January 1998 to May 2008. RESULTS: Bone metastasis was identified in 203 (2.4%) of 8,633 patients: 126 patients (62%) with synchronous metastasis and 77 patients with metachronous metastasis. The median time to event was 16 months (range 4-87). As for treatment, 120 patients (59%) received systemic chemotherapy. The median survival time was 103 days (95% CI 80-126). Poor performance status [Eastern Cooperative Oncology Group 3-4; relative risk (RR) = 1.91, p = 0.011], multiple bone metastasis (RR = 2.593, p = 0.002), and abnormal carcinoembryonic antigen (RR = 1.779, p = 0.004) implied independent factors for survival. For patients who had zero to two of these factors identified, chemotherapy had a beneficial effect (175 vs. 43 days; p < 0.0001). CONCLUSION: We recommend that the therapeutic approach with bone metastasis be customized to facilitate the risk stratification, so as to consequently provide the most appropriate therapy for each patient.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김효송(Kim, Hyo Song) ; 노성훈(Noh, Sung Hoon) ; 라선영(Rha, Sun Young) ; 정현철(Chung, Hyun Cheol) ; 정희철(Jeung, Hei Cheul) ; 형우진(Hyung, Woo Jin)
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