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Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma: correlation with histological characteristics.

 Jin-Young Choi  ;  Myeong-Jin Kim  ;  Young Nyun Park  ;  Jeong Min Lee  ;  Sun Kook Yoo  ;  Sun Young Rha  ;  Jae Yeon SeokRead More: http://www.ajronline.org/doi/abs/10.2214/AJR.10.5439 
 AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.197(2) : 399-405, 2011 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Carcinoma, Hepatocellular/pathology* ; Carcinoma, Hepatocellular/surgery ; Contrast Media* ; Female ; Gadolinium DTPA* ; Humans ; Keratin-19/analysis ; Keratin-7 ; Liver Neoplasms/pathology* ; Liver Neoplasms/surgery ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Retrospective Studies ; Statistics, Nonparametric
contrast agent ; hepatocellular carcinoma ; MRI
OBJECTIVE: The purpose of this study was to assess whether gadoxetate disodium-enhanced hepatobiliary phase MRI could predict the histologic factors of hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: Fifty-three HCCs histopathologically proved by surgery in 51 patients were evaluated retrospectively. All patients underwent gadoxetate disodium-enhanced MRI before surgical resection. The differences in contrast enhancement ratio of the lesions and differences in contrast-to-noise ratio (CNR) among the histologic grades of HCC were compared by using the Kruskal-Wallis test. The Spearman method was used to determine the correlations among contrast enhancement ratio, CNR, cell density ratio, and positivity for anti-hepatocyte antibody, keratin 7, and keratin 19. RESULTS: Of 53 HCCs, 50 showed low signal intensity on hepatobiliary phase images, whereas three HCCs were hyperintense on hepatobiliary phase images compared with surrounding hepatic parenchyma. Although well-differentiated HCCs tended to show higher contrast enhancement, there was no statistical significance between contrast enhancement ratio of the tumors and histologic grade (p = 0.414). No significant difference was observed between CNR and histologic grade (p = 0.965). The contrast enhancement ratios of the tumors were significantly lower in the keratin 19-positive group than in the keratin 19-negative group (p = 0.015). There was no significant correlation among contrast enhancement ratio, anti-hepatocyte antibody positivity, cell density ratio, and keratin 7 positivity (p > 0.05). CONCLUSION: The contrast enhancement ratio and CNR of HCCs were not correlated with histologic grades. The contrast enhancement ratio was significantly lower in keratin 19-positive HCCs.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Kim, Yeo Eun(김여은)
Lee, Jong Doo(이종두)
Chung, Woo Seok(정우석)
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