8 201

Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma: correlation with histological characteristics.

Authors
 Jin-Young Choi  ;  Myeong-Jin Kim  ;  Young Nyun Park  ;  Jeong Min Lee  ;  Sun Kook Yoo  ;  Sun Young Rha  ;  Jae Yeon SeokRead More: http://www.ajronline.org/doi/abs/10.2214/AJR.10.5439 
Citation
 American Journal of Roentgenology, Vol.197(2) : 399-405, 2011 
Journal Title
 American Journal of Roentgenology 
ISSN
 0361-803X 
Issue Date
2011
Abstract
OBJECTIVE: The purpose of this study was to assess whether gadoxetate disodium-enhanced hepatobiliary phase MRI could predict the histologic factors of hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: Fifty-three HCCs histopathologically proved by surgery in 51 patients were evaluated retrospectively. All patients underwent gadoxetate disodium-enhanced MRI before surgical resection. The differences in contrast enhancement ratio of the lesions and differences in contrast-to-noise ratio (CNR) among the histologic grades of HCC were compared by using the Kruskal-Wallis test. The Spearman method was used to determine the correlations among contrast enhancement ratio, CNR, cell density ratio, and positivity for anti-hepatocyte antibody, keratin 7, and keratin 19. RESULTS: Of 53 HCCs, 50 showed low signal intensity on hepatobiliary phase images, whereas three HCCs were hyperintense on hepatobiliary phase images compared with surrounding hepatic parenchyma. Although well-differentiated HCCs tended to show higher contrast enhancement, there was no statistical significance between contrast enhancement ratio of the tumors and histologic grade (p = 0.414). No significant difference was observed between CNR and histologic grade (p = 0.965). The contrast enhancement ratios of the tumors were significantly lower in the keratin 19-positive group than in the keratin 19-negative group (p = 0.015). There was no significant correlation among contrast enhancement ratio, anti-hepatocyte antibody positivity, cell density ratio, and keratin 7 positivity (p > 0.05). CONCLUSION: The contrast enhancement ratio and CNR of HCCs were not correlated with histologic grades. The contrast enhancement ratio was significantly lower in keratin 19-positive HCCs.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93597
Full Text
http://www.ajronline.org/doi/abs/10.2214/AJR.10.5439
DOI
abs/10.2214/AJR.10.5439
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
Yonsei Authors
김명진(Kim, Myeong Jin) ORCID logo https://orcid.org/0000-0001-7949-5402
김여은(Kim, Yeo Eun)
이종두(Lee, Jong Doo)
정우석(Chung, Woo Seok)
Export
RIS (EndNote)
XLS (Excel)
XML
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse