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Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma: correlation with histological characteristics.
DC Field | Value | Language |
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dc.contributor.author | 김명진 | - |
dc.contributor.author | 김여은 | - |
dc.contributor.author | 이종두 | - |
dc.contributor.author | 정우석 | - |
dc.date.accessioned | 2014-12-20T16:54:12Z | - |
dc.date.available | 2014-12-20T16:54:12Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0361-803X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93597 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study was to assess whether gadoxetate disodium-enhanced hepatobiliary phase MRI could predict the histologic factors of hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: Fifty-three HCCs histopathologically proved by surgery in 51 patients were evaluated retrospectively. All patients underwent gadoxetate disodium-enhanced MRI before surgical resection. The differences in contrast enhancement ratio of the lesions and differences in contrast-to-noise ratio (CNR) among the histologic grades of HCC were compared by using the Kruskal-Wallis test. The Spearman method was used to determine the correlations among contrast enhancement ratio, CNR, cell density ratio, and positivity for anti-hepatocyte antibody, keratin 7, and keratin 19. RESULTS: Of 53 HCCs, 50 showed low signal intensity on hepatobiliary phase images, whereas three HCCs were hyperintense on hepatobiliary phase images compared with surrounding hepatic parenchyma. Although well-differentiated HCCs tended to show higher contrast enhancement, there was no statistical significance between contrast enhancement ratio of the tumors and histologic grade (p = 0.414). No significant difference was observed between CNR and histologic grade (p = 0.965). The contrast enhancement ratios of the tumors were significantly lower in the keratin 19-positive group than in the keratin 19-negative group (p = 0.015). There was no significant correlation among contrast enhancement ratio, anti-hepatocyte antibody positivity, cell density ratio, and keratin 7 positivity (p > 0.05). CONCLUSION: The contrast enhancement ratio and CNR of HCCs were not correlated with histologic grades. The contrast enhancement ratio was significantly lower in keratin 19-positive HCCs. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF ROENTGENOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biomarkers, Tumor/analysis | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/surgery | - |
dc.subject.MESH | Contrast Media* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gadolinium DTPA* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Keratin-19/analysis | - |
dc.subject.MESH | Keratin-7 | - |
dc.subject.MESH | Liver Neoplasms/pathology* | - |
dc.subject.MESH | Liver Neoplasms/surgery | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.title | Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma: correlation with histological characteristics. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Jin-Young Choi | - |
dc.contributor.googleauthor | Myeong-Jin Kim | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Jeong Min Lee | - |
dc.contributor.googleauthor | Sun Kook Yoo | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Jae Yeon SeokRead More: http://www.ajronline.org/doi/abs/10.2214/AJR.10.5439 | - |
dc.identifier.doi | abs/10.2214/AJR.10.5439 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A00688 | - |
dc.contributor.localId | A03138 | - |
dc.contributor.localId | A03666 | - |
dc.relation.journalcode | J00116 | - |
dc.identifier.eissn | 1546-3141 | - |
dc.identifier.pmid | 21785086 | - |
dc.identifier.url | http://www.ajronline.org/doi/abs/10.2214/AJR.10.5439 | - |
dc.subject.keyword | contrast agent | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | MRI | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.alternativeName | Kim, Yeo Eun | - |
dc.contributor.alternativeName | Lee, Jong Doo | - |
dc.contributor.alternativeName | Chung, Woo Seok | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | Kim, Yeo Eun | - |
dc.contributor.affiliatedAuthor | Lee, Jong Doo | - |
dc.contributor.affiliatedAuthor | Chung, Woo Seok | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 197 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 399 | - |
dc.citation.endPage | 405 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.197(2) : 399-405, 2011 | - |
dc.identifier.rimsid | 28332 | - |
dc.type.rims | ART | - |
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