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Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma: correlation with histological characteristics.

DC FieldValueLanguage
dc.contributor.author김명진-
dc.contributor.author김여은-
dc.contributor.author이종두-
dc.contributor.author정우석-
dc.date.accessioned2014-12-20T16:54:12Z-
dc.date.available2014-12-20T16:54:12Z-
dc.date.issued2011-
dc.identifier.issn0361-803X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93597-
dc.description.abstractOBJECTIVE: The purpose of this study was to assess whether gadoxetate disodium-enhanced hepatobiliary phase MRI could predict the histologic factors of hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: Fifty-three HCCs histopathologically proved by surgery in 51 patients were evaluated retrospectively. All patients underwent gadoxetate disodium-enhanced MRI before surgical resection. The differences in contrast enhancement ratio of the lesions and differences in contrast-to-noise ratio (CNR) among the histologic grades of HCC were compared by using the Kruskal-Wallis test. The Spearman method was used to determine the correlations among contrast enhancement ratio, CNR, cell density ratio, and positivity for anti-hepatocyte antibody, keratin 7, and keratin 19. RESULTS: Of 53 HCCs, 50 showed low signal intensity on hepatobiliary phase images, whereas three HCCs were hyperintense on hepatobiliary phase images compared with surrounding hepatic parenchyma. Although well-differentiated HCCs tended to show higher contrast enhancement, there was no statistical significance between contrast enhancement ratio of the tumors and histologic grade (p = 0.414). No significant difference was observed between CNR and histologic grade (p = 0.965). The contrast enhancement ratios of the tumors were significantly lower in the keratin 19-positive group than in the keratin 19-negative group (p = 0.015). There was no significant correlation among contrast enhancement ratio, anti-hepatocyte antibody positivity, cell density ratio, and keratin 7 positivity (p > 0.05). CONCLUSION: The contrast enhancement ratio and CNR of HCCs were not correlated with histologic grades. The contrast enhancement ratio was significantly lower in keratin 19-positive HCCs.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfAMERICAN JOURNAL OF ROENTGENOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers, Tumor/analysis-
dc.subject.MESHCarcinoma, Hepatocellular/pathology*-
dc.subject.MESHCarcinoma, Hepatocellular/surgery-
dc.subject.MESHContrast Media*-
dc.subject.MESHFemale-
dc.subject.MESHGadolinium DTPA*-
dc.subject.MESHHumans-
dc.subject.MESHKeratin-19/analysis-
dc.subject.MESHKeratin-7-
dc.subject.MESHLiver Neoplasms/pathology*-
dc.subject.MESHLiver Neoplasms/surgery-
dc.subject.MESHMagnetic Resonance Imaging/methods*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStatistics, Nonparametric-
dc.titleGadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma: correlation with histological characteristics.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorJin-Young Choi-
dc.contributor.googleauthorMyeong-Jin Kim-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorJeong Min Lee-
dc.contributor.googleauthorSun Kook Yoo-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorJae Yeon SeokRead More: http://www.ajronline.org/doi/abs/10.2214/AJR.10.5439-
dc.identifier.doiabs/10.2214/AJR.10.5439-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00426-
dc.contributor.localIdA00688-
dc.contributor.localIdA03138-
dc.contributor.localIdA03666-
dc.relation.journalcodeJ00116-
dc.identifier.eissn1546-3141-
dc.identifier.pmid21785086-
dc.identifier.urlhttp://www.ajronline.org/doi/abs/10.2214/AJR.10.5439-
dc.subject.keywordcontrast agent-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordMRI-
dc.contributor.alternativeNameKim, Myeong Jin-
dc.contributor.alternativeNameKim, Yeo Eun-
dc.contributor.alternativeNameLee, Jong Doo-
dc.contributor.alternativeNameChung, Woo Seok-
dc.contributor.affiliatedAuthorKim, Myeong Jin-
dc.contributor.affiliatedAuthorKim, Yeo Eun-
dc.contributor.affiliatedAuthorLee, Jong Doo-
dc.contributor.affiliatedAuthorChung, Woo Seok-
dc.rights.accessRightsnot free-
dc.citation.volume197-
dc.citation.number2-
dc.citation.startPage399-
dc.citation.endPage405-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF ROENTGENOLOGY, Vol.197(2) : 399-405, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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