2 182

Cited 14 times in

Predictive values of 5-fluorouracil pathway genes for S-1 treatment in patients with advanced gastric cancer

 Jeung, Hei-Cheula,b,c  ;  Rha, Sun Younga,b,c  ;  Shin, Sang Joona,c  ;  Lim, Seung Joonb  ;  Roh, Jae Kyunga,b,c  ;  Noh, Sung Hoond  ;  Chung, Hyun Cheola, 
 ANTI-CANCER DRUGS, Vol.22(8) : 801-810, 2011 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Antimetabolites, Antineoplastic/metabolism ; Antimetabolites, Antineoplastic/pharmacology* ; Disease-Free Survival ; Drug Combinations ; Female ; Fluorouracil/metabolism ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic* ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Oxonic Acid/pharmacology* ; Polymerase Chain Reaction ; RNA, Messenger/metabolism ; Retrospective Studies ; Stomach Neoplasms/drug therapy* ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Survival ; Tegafur/pharmacology* ; Treatment Outcome ; Young Adult
gastric cancer ; orotate phosphoribosyltransferase ; S-1 ; thymidine phosphorylase ; thymidylate synthase
Determination of significant associations between gene expression and predefined endpoints might improve treatment tailoring for advanced gastric cancer. We investigated the mRNA expression of 5-fluorouracil (5-FU) pathway genes in prechemotherapeutic tumor samples of primary gastric cancer to try to predict the treatment outcome of S-1 monotherapy. 5-FU pathway genes, dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyltransferase (OPRT), thymidylate synthase (TS), and thymidine phosphorylase (TP), were analyzed using quantitative real-time PCR of RNA extracted from archived formalin-fixed paraffin-embedded tissues. We selected the median value for each gene as a cutoff to separate patients into high and low gene expression groups. High OPRT gene expression was significantly associated with tumor response (P = 0.014). In a combined analysis including OPRT, patients with high OPRT and TP showed a higher overall response rate than did the remaining patients (40 vs. 10%, respectively; P = 0.002). For survival, patients with high OPRT and low TS levels showed prolonged survival in both progression-free survival (3.4 vs. 2.4 months, P = 0.024) and overall survival (11.0 vs. 8.2 months, P = 0.007). In a multivariate analysis, the combinations of OPRT and TP for response and OPRT and TS for both progression-free survival and overall survival were independent variables. To conclude, mRNA expression levels of molecular markers in formalin-fixed paraffin-embedded specimens of primary gastric tumors can be useful for identifying patients with advanced gastric cancer who would most likely benefit from S-1 treatment.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.