Cited 16 times in
Predictive values of 5-fluorouracil pathway genes for S-1 treatment in patients with advanced gastric cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신상준 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 정희철 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.date.accessioned | 2014-12-20T16:53:26Z | - |
dc.date.available | 2014-12-20T16:53:26Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0959-4973 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93573 | - |
dc.description.abstract | Determination of significant associations between gene expression and predefined endpoints might improve treatment tailoring for advanced gastric cancer. We investigated the mRNA expression of 5-fluorouracil (5-FU) pathway genes in prechemotherapeutic tumor samples of primary gastric cancer to try to predict the treatment outcome of S-1 monotherapy. 5-FU pathway genes, dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyltransferase (OPRT), thymidylate synthase (TS), and thymidine phosphorylase (TP), were analyzed using quantitative real-time PCR of RNA extracted from archived formalin-fixed paraffin-embedded tissues. We selected the median value for each gene as a cutoff to separate patients into high and low gene expression groups. High OPRT gene expression was significantly associated with tumor response (P = 0.014). In a combined analysis including OPRT, patients with high OPRT and TP showed a higher overall response rate than did the remaining patients (40 vs. 10%, respectively; P = 0.002). For survival, patients with high OPRT and low TS levels showed prolonged survival in both progression-free survival (3.4 vs. 2.4 months, P = 0.024) and overall survival (11.0 vs. 8.2 months, P = 0.007). In a multivariate analysis, the combinations of OPRT and TP for response and OPRT and TS for both progression-free survival and overall survival were independent variables. To conclude, mRNA expression levels of molecular markers in formalin-fixed paraffin-embedded specimens of primary gastric tumors can be useful for identifying patients with advanced gastric cancer who would most likely benefit from S-1 treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 801~810 | - |
dc.relation.isPartOf | ANTI-CANCER DRUGS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antimetabolites, Antineoplastic/metabolism | - |
dc.subject.MESH | Antimetabolites, Antineoplastic/pharmacology* | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Drug Combinations | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorouracil/metabolism | - |
dc.subject.MESH | Gene Expression Regulation, Enzymologic | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Oxonic Acid/pharmacology* | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Stomach Neoplasms/drug therapy* | - |
dc.subject.MESH | Stomach Neoplasms/genetics | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | Survival | - |
dc.subject.MESH | Tegafur/pharmacology* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Predictive values of 5-fluorouracil pathway genes for S-1 treatment in patients with advanced gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jeung, Hei-Cheula,b,c | - |
dc.contributor.googleauthor | Rha, Sun Younga,b,c | - |
dc.contributor.googleauthor | Shin, Sang Joona,c | - |
dc.contributor.googleauthor | Lim, Seung Joonb | - |
dc.contributor.googleauthor | Roh, Jae Kyunga,b,c | - |
dc.contributor.googleauthor | Noh, Sung Hoond | - |
dc.contributor.googleauthor | Chung, Hyun Cheola, | - |
dc.identifier.doi | 10.1097/CAD.0b013e328345c9ae | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A03794 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J00187 | - |
dc.identifier.eissn | 1473-5741 | - |
dc.identifier.pmid | 21572321 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001813-201109000-00011&LSLINK=80&D=ovft | - |
dc.subject.keyword | gastric cancer | - |
dc.subject.keyword | orotate phosphoribosyltransferase | - |
dc.subject.keyword | S-1 | - |
dc.subject.keyword | thymidine phosphorylase | - |
dc.subject.keyword | thymidylate synthase | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.affiliatedAuthor | Shin, Sang Joon | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Roh, Jae Kyung | - |
dc.contributor.affiliatedAuthor | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 22 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 801 | - |
dc.citation.endPage | 810 | - |
dc.identifier.bibliographicCitation | ANTI-CANCER DRUGS, Vol.22(8) : 801-810, 2011 | - |
dc.identifier.rimsid | 28318 | - |
dc.type.rims | ART | - |
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